The role of the immune system in early epithelial carcinogenesis: B-ware the double-edged sword Journal Article
| Authors: | Houghton, A. N.; Uchi, H.; Wolchok, J. D. |
| Article Title: | The role of the immune system in early epithelial carcinogenesis: B-ware the double-edged sword |
| Abstract: | Cancer is commonly described as a disease of genetic mutations. However, epidemiologic and clinical evidence points to the important but multifaceted role of the host. The immune system has something to say about cancer evolution through promotion of malignancy by inflammatory myeloid cells of the innate immune system. In a report in this issue of Cancer Cell, B cells are implicated as key players in the regulation of chronic inflammation that promotes early events in epithelial carcinogenesis. These are surprising observations, linking antibodies of the adaptive immune system to innate immune responses that drive epithelial carcinogenesis. Copyright © 2005 Elsevier Inc. |
| Keywords: | signal transduction; epidermal growth factor; platelet derived growth factor; vasculotropin; gene mutation; nonhuman; cell proliferation; animals; mice; cell survival; cell division; cell function; metastasis; apoptosis; immune system; transforming growth factor beta; gelatinase b; interleukin 10; inflammation; angiogenesis; b lymphocyte; carcinogenesis; b-lymphocytes; cancer invasion; scatter factor; chronic disease; cellular immunity; immune response; chemokine; prostaglandin e2; interleukin 6; natural killer cell; short survey; innate immunity; tumor promotion; indoleamine 2,3 dioxygenase; macrophages; superoxide; t lymphocyte activation; chronic inflammation; fibroblast growth factor; nitric oxide synthase; tumor necrosis factor; neoplasms, glandular and epithelial; interleukin 1; urokinase receptor; plasmin; models, immunological; immunologic surveillance; immunity, natural; peroxynitrite |
| Journal Title: | Cancer Cell |
| Volume: | 7 |
| Issue: | 5 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2005-05-01 |
| Start Page: | 403 |
| End Page: | 405 |
| Language: | English |
| DOI: | 10.1016/j.ccr.2005.04.026 |
| PUBMED: | 15894259 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 12" - "Export Date: 24 October 2012" - "CODEN: CCAEC" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work