Identifying site-specific metastasis genes and functions Conference Paper

  


Authors: Gupta, G. P.; Minn, A. J.; Kang, Y.; Siegel, P. M.; Serganova, I.; Cordon-Cardo, C.; Olshen, A. B.; Gerald, W. L.; Massague, J.
Title: Identifying site-specific metastasis genes and functions
Conference Title: 70th Cold Spring Harbor Symposium on Quantitative Biology
Abstract: Metastasis is a multistep and multifunctional biological cascade that is the final and most life-threatening stage of cancer progression. Understanding the biological underpinnings of this complex process is of extreme clinical relevance and requires unbiased and comprehensive biological scrutiny. In recent years, we have utilized a xenograft model of breast cancer metastasis to discover genes that mediate organ-specific patterns of metastatic colonization. Examination of transcriptomic data from cohorts of primary breast cancers revealed a subset of site-specific metastasis genes that are selected for early in tumor progression. High expression of these genes predicts the propensity for lung metastasis independently of several classic markers of poor prognosis. These genes fulfill dual functions - enhanced primary tumorigenicity and augmented organ-specific metastatic activity. Other metastasis genes fulfill functions specialized for the microenvironment of the metastatic site and are consequently not selected for in primary tumors. These findings improve our understanding of metastatic progression, facilitate the interpretation of primary tumor gene expression data, and open several important possibilities for future clinical application. © 2005 Cold Spring Harbor Laboratory Press.
Keywords: bone neoplasms; cancer growth; nonhuman; conference paper; animals; mice; metastasis; breast cancer; gene expression; gene expression profiling; lung neoplasms; cohort analysis; lung cancer; gene function; cell population; cell line, tumor; breast neoplasms; oncogenes; oncogene; xenograft; carcinogenicity; neoplasm metastasis; organ specificity; transplantation, heterologous; neoplasm transplantation; genetic heterogeneity; bone cancer; disease activity
Journal Title Cold Spring Harbor Symposia on Quantitative Biology
Volume: 70
Conference Dates: 2005 Jun 1-6
Conference Location: Cold Spring Harbor, NY
ISBN: 0091-7451
Publisher: Cold Spring Harbor Laboratory Press  
Date Published: 2005-01-01
Start Page: 149
End Page: 158
Language: English
DOI: 10.1101/sqb.2005.70.018
PUBMED: 16869748
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-33746407123&partnerID=40&md5=d22dbfdf2c276935bfce234ce86f4fd9
Notes: --- - "Cited By (since 1996): 29" - "Export Date: 24 October 2012" - "CODEN: CSHSA" - "Source: Scopus"
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MSK Authors
  1. Andy Minn
    7 Minn
  2. Yibin Kang
    13 Kang
  3. Peter M Siegel
    10 Siegel
  4. William L Gerald
    375 Gerald
  5. Carlos Cordon-Cardo
    612 Cordon-Cardo
  6. Adam B Olshen
    107 Olshen
  7. Gaorav Gupta
    37 Gupta
  8. Joan Massague
    388 Massague
  9. Inna Serganova
    95 Serganova
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