Tumor entrained neutrophils inhibit seeding in the premetastatic lung Journal Article
| Authors: | Granot, Z.; Henke, E.; Comen, E.; King, T.; Norton, L.; Benezra, R. |
| Article Title: | Tumor entrained neutrophils inhibit seeding in the premetastatic lung |
| Abstract: | Primary tumors have been shown to prepare distal organs for later colonization of metastatic cells by stimulating organ-specific infiltration of bone marrow derived cells. Here we demonstrate that neutrophils accumulate in the lung prior to the arrival of metastatic cells in mouse models of breast cancer. Tumor-entrained neutrophils (TENs) inhibit metastatic seeding in the lungs by generating H2O2 and tumor secreted CCL2 is a critical mediator of optimal antimetastatic entrainment of G-CSF-stimulated neutrophils. TENs are present in the peripheral blood of breast cancer patients prior to surgical resection but not in healthy individuals. Thus, whereas tumor-secreted factors contribute to tumor progression at the primary site, they concomitantly induce a neutrophil-mediated inhibitory process at the metastatic site. © 2011 Elsevier Inc. |
| Journal Title: | Cancer Cell |
| Volume: | 20 |
| Issue: | 3 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2011-09-13 |
| Start Page: | 300 |
| End Page: | 314 |
| Language: | English |
| DOI: | 10.1016/j.ccr.2011.08.012 |
| PROVIDER: | scopus |
| PMCID: | PMC3172582 |
| PUBMED: | 21907922 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 October 2011" - "CODEN: CCAEC" - "Source: Scopus" |
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