Diagnosis and treatment of primary central nervous system lymphoma Journal Article
| Authors: | Gavrilovic, I. T.; Abrey, L. E. |
| Article Title: | Diagnosis and treatment of primary central nervous system lymphoma |
| Abstract: | Primary central nervous system lymphoma (PCNSL) is an uncommon form of non-Hodgkin's lymphoma (NHL) that has been increasing in incidence over the past three decades. Unlike systemic extranodal NHL, the response to therapy for PCNSL patients has been somewhat unsatisfactory. However, methotrexate-based chemotherapy and whole-brain radiotherapy have improved the outcome of patients. Unfortunately, treatment-related neurotoxicity is common, especially in the elderly. Although progress has been made in treating PCNSL, there remains no optimal methotrexate dose or frequency. Treatment of recurrence also remains controversial. These important questions have prompted several clinical studies looking at novel ways to intensify chemotherapy and limit neurotoxicity. Copyright © 2005 by Current Science Inc. |
| Keywords: | cancer survival; treatment outcome; survival rate; prednisone; clinical trial; review; doxorubicin; cancer risk; drug penetration; antineoplastic agents; cytarabine; methotrexate; rituximab; temozolomide; topotecan; neurotoxicity; nuclear magnetic resonance imaging; positron emission tomography; magnetic resonance imaging; cancer incidence; carboplatin; computer assisted tomography; etoposide; recurrence; cytogenetics; cyclophosphamide; dexamethasone; melphalan; vincristine; stem cell transplantation; diagnostic imaging; protein p53; carmustine; ifosfamide; lomustine; procarbazine; thiotepa; central nervous system tumor; risk assessment; central nervous system neoplasms; imaging system; chromosome aberration; nonhodgkin lymphoma; brain; urine incontinence; drug response; blood brain barrier; lymphoma; dementia; medical oncology; methylprednisolone; acquired immune deficiency syndrome; antiretrovirus agent; highly active antiretroviral therapy; molecular biology; corticosteroid; chromosome loss; comparative genomic hybridization; ataxia; leukoencephalopathy; clinical trials; teniposide; brain edema; consciousness disorder; eye tumor; thiosulfate |
| Journal Title: | Current Oncology Reports |
| Volume: | 7 |
| Issue: | 1 |
| ISSN: | 1523-3790 |
| Publisher: | Springer |
| Date Published: | 2005-01-01 |
| Start Page: | 47 |
| End Page: | 54 |
| Language: | English |
| PUBMED: | 15610686 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 4" - "Export Date: 24 October 2012" - "CODEN: CORUA" - "Source: Scopus" |
