Primary central nervous system lymphoma Journal Article
| Authors: | Gavrilovic, I. T.; Abrey, L. E. |
| Article Title: | Primary central nervous system lymphoma |
| Abstract: | Primary central nervous system lymphoma. (PCNSL) is a rare variant of non-Hodgkin's lymphoma that is increasing in incidence. Methotrexate-based chemotherapy in combination with whole-brain radiotherapy (WBRT) has dramatically improved the outcome of patients, However, treatment-related neurotoxicity is a significant complication, especially after radiotherapy in the elderly. Despite advances in therapy, several important questions remain regarding optimal methotrexate dose, dosing frequency, adjunct chemotherapy, and the impact of deferring WBRT. Advances in biologic therapy and strategies to intensify the delivery of chemotherapy may help to limit the use of radiotherapy, thus lessening potential neurotoxicity. Studies looking at oncogenic proteins as potential prognostic markers for PCNSL may help us to develop risk-adapted therapies. Copyright © 2004 by Current Science Inc. |
| Keywords: | cancer survival; treatment outcome; oncoprotein; prednisone; clinical trial; histopathology; review; doxorubicin; dose response; antineoplastic agents; united states; cancer radiotherapy; cytarabine; gadolinium; methotrexate; rituximab; temozolomide; nuclear magnetic resonance imaging; positron emission tomography; magnetic resonance imaging; cancer incidence; carboplatin; computer assisted tomography; etoposide; radiotherapy; prevalence; creatinine; cyclophosphamide; dexamethasone; melphalan; vincristine; carmustine; lomustine; procarbazine; thiotepa; risk assessment; central nervous system neoplasms; risk; nonhodgkin lymphoma; brain; lumbar puncture; bone marrow biopsy; medical oncology; lactate dehydrogenase; methylprednisolone; protein bcl 6; idarubicin; corticosteroid; brain biopsy; single photon emission computer tomography; drug dose regimen; neurologic disease; elderly care; canada; autologous hematopoietic stem cell transplantation; leukoencephalopathy; brain surgery; drug delivery system; stereotaxic surgery; brain lymphoma; slit lamp; biochemical marker; thiosulfate; humans; prognosis; human |
| Journal Title: | Current Oncology Reports |
| Volume: | 6 |
| Issue: | 5 |
| ISSN: | 1523-3790 |
| Publisher: | Springer |
| Date Published: | 2004-01-01 |
| Start Page: | 388 |
| End Page: | 395 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 15291982 |
| DOI: | 10.1007/s11912-004-0065-7 |
| DOI/URL: | |
| Notes: | Curr. Oncol. Rep. -- Cited By (since 1996):5 -- Export Date: 16 June 2014 -- CODEN: CORUA C2 - 15291982 -- Source: Scopus |
