Treatment of primary central nervous system lymphoma with cranial irradiation and combined modality therapy Book Section
| Authors: | Deangelis, L. M.; Yahalom, J. |
| Editors: | Batchelor, T.; Deangelis, L. M. |
| Article/Chapter Title: | Treatment of primary central nervous system lymphoma with cranial irradiation and combined modality therapy |
| Abstract: | Whole brain radiotherapy (WBRT) has long been recognized as an effective treatment for PCNSL. WBRT alone leads to tumor regression and prolongs median survival to approximately 12–18 months. However, disease returns in almost all patients. Adding chemotherapy to WBRT was the first step towards prolonging remission and survival in these patients. Through a series of studies, it is clear that high-dose methotrexate (MTX) is the single most effective agent for the treatment of PCNSL. However, whether MTX is used as a single agent or in combination with other drugs, it has the potential of causing long-term neurological sequelae when combined with WBRT, particularly in older patients. Recent data suggest that reducing the dose of WBRT may prove effective at enhancing disease control without causing neurotoxicity. Furthermore, WBRT remains an effective and important salvage therapy for those patients who recur after chemotherapy alone. © Springer Science+Business Media, LLC 2012. All rights reserved. |
| Book Title: | Lymphoma and Leukemia of the Nervous System. 2nd ed |
| ISBN: | 978-1-4419-7667-3 |
| Publisher: | Springer |
| Publication Place: | New York, NY |
| Date Published: | 2012-01-01 |
| Start Page: | 129 |
| End Page: | 139 |
| Language: | English |
| DOI: | 10.1007/978-1-4419-7668-0_7 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book Chapter: 7 -- Lymphoma and Leukemia of the Nerv. System -- 9781441976680 (eISBN); 9781441976673 (ISBN) -- Export Date: 3 February 2016 -- Source: Scopus |
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