Primary central nervous system lymphomas Journal Article
| Author: | Deangelis, L. M. |
| Article Title: | Primary central nervous system lymphomas |
| Abstract: | Primary central nervous system lymphoma (PCNSL) is widely regarded as one of the primary brain tumors most amenable to treatment. Although whole brain radiotherapy was the cornerstone of therapy for decades, recent work clearly indicates that chemotherapy has become the primary focus of treatment for this disease. The initial treatment of PCNSL for all patients, including the elderly, should be chemotherapy using a high-dose methotrexate-based regimen. Although cranial irradiation has often been combined with methotrexate, the unacceptably high incidence of late neurotoxicity, particularly in older patients, has caused many to eliminate radiotherapy, especially in those older than age 60 years. Emerging data support the validity of this approach, and the development of more efficacious chemotherapeutic regimens has been the focus of recent research. |
| Keywords: | survival; adult; treatment outcome; aged; middle aged; survival analysis; review; multimodality cancer therapy; combined modality therapy; methotrexate; brain tumor; methodology; brain neoplasms; antineoplastic agent; antineoplastic combined chemotherapy protocols; pathology; diagnostic imaging; biopsy; skull irradiation; cranial irradiation; cancer invasion; b cell lymphoma; nonhodgkin lymphoma; meninges; lymphoma, non-hodgkin; craniotomy; neoplasm invasiveness; seizure; anticonvulsive agent; corticosteroid; drug contraindication; lymphoma, aids-related; anticonvulsants; injections, spinal; eye; stereotaxic surgery; seizures; stereotaxic techniques; adrenal cortex hormones; vitrectomy; meninx; humans; human; intraspinal drug administration |
| Journal Title: | Current Treatment Options in Oncology |
| Volume: | 2 |
| Issue: | 4 |
| ISSN: | 1527-2729 |
| Publisher: | Springer |
| Date Published: | 2001-07-01 |
| Start Page: | 309 |
| End Page: | 318 |
| Language: | English |
| PUBMED: | 12057111 |
| PROVIDER: | scopus |
| DOI: | 10.1007/s11864-001-0024-6 |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
