Primary central nervous system lymphoma Journal Article
| Author: | Abrey, L. E. |
| Article Title: | Primary central nervous system lymphoma |
| Abstract: | PURPOSE OF REVIEW: This review will summarize recent advances in the understanding and treatment of primary central nervous system lymphoma (PCNSL). RECENT FINDINGS: The molecular and genetic characteristics that distinguish PCNSL are beginning to be elucidated. New tools such as flow cytometry and PET are improving the diagnosis and management of PCNSL. Although the current standard of care is high-dose methotrexate-based chemotherapy alone or in combination with whole brain radiotherapy, multiple questions remain regarding the optimal treatment of PCNSL, in general, and unusual variants of PCNSL. SUMMARY: Although recent advances have improved our understanding of PCNSL, the need for additional collaborative research is critical. © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins. |
| Keywords: | overall survival; clinical feature; review; cancer localization; cancer radiotherapy; chemotherapy; molecular genetic characteristics; primary central nervous system lymphoma; treatment; cytarabine; gadolinium; ibritumomab tiuxetan; methotrexate; rituximab; temozolomide; topotecan; brain radiation; cancer staging; drug megadose; flow cytometry; human immunodeficiency virus infection; molecular genetics; neuroimaging; neurotoxicity; nuclear magnetic resonance imaging; outcome assessment; positron emission tomography; recurrence risk; recurrent cancer |
| Journal Title: | Current Opinion in Neurology |
| Volume: | 22 |
| Issue: | 6 |
| ISSN: | 1350-7540 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2009-11-01 |
| Start Page: | 675 |
| End Page: | 680 |
| Language: | English |
| DOI: | 10.1097/WCO.0b013e328332533b |
| PROVIDER: | scopus |
| PUBMED: | 19741527 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: CONEE" - "Source: Scopus" |
