Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma Journal Article
| Authors: | Deckert, M.; Engert, A.; Brück, W.; Ferreri, A. J. M.; Finke, J.; Illerhaus, G.; Klapper, W.; Korfel, A.; Küppers, R.; Maarouf, M.; Montesinos-Rongen, M.; Paulus, W.; Schlegel, U.; Lassmann, H.; Wiestler, O. D.; Siebert, R.; Deangelis, L. M. |
| Article Title: | Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma |
| Abstract: | Recent studies addressing the molecular characteristics of PCNSL, which is defined as malignant B-cell lymphoma with morphological features of DLBCL, have significantly improved our understanding of the pathogenesis of this lymphoma entity, which is associated with an inferior prognosis as compared with DLBCL outside the CNS. This unfavorable prognosis stimulated intense efforts to improve therapy and induced recent series of clinical studies, which addressed the role of radiotherapy and various chemotherapeutic regimens. This review combines the discussion of diagnosis, differential diagnosis and recent progress in studies addressing the molecular pathogenesis as well as therapeutic options in PCNSL. © 2011 Macmillan Publishers Limited All rights reserved. |
| Keywords: | treatment response; busulfan; prednisone; clinical feature; histopathology; pathogenesis; review; doxorubicin; drug efficacy; drug safety; nonhuman; chemotherapy; primary central nervous system lymphoma; cytarabine; methotrexate; rituximab; temozolomide; topotecan; drug megadose; neurotoxicity; ki 67 antigen; biological marker; phenotype; protein bcl 2; multiple cycle treatment; etoposide; blood toxicity; radiotherapy; differential diagnosis; cyclophosphamide; vincristine; autologous stem cell transplantation; tumor regression; carmustine; ifosfamide; procarbazine; thiotepa; central nervous system neoplasms; b cell lymphoma; cd20 antigen; whole body radiation; drug mechanism; virus rna; blood brain barrier; bleomycin; large cell lymphoma; idarubicin; primary cns lymphoma; brain biopsy; teniposide; diffuse large b-cell lymphoma; common acute lymphoblastic leukemia antigen; molecular pathology; randomized controlled trial (topic); phase 3 clinical trial (topic) |
| Journal Title: | Leukemia |
| Volume: | 25 |
| Issue: | 12 |
| ISSN: | 0887-6924 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2011-12-01 |
| Start Page: | 1797 |
| End Page: | 1807 |
| Language: | English |
| DOI: | 10.1038/leu.2011.169 |
| PROVIDER: | scopus |
| PUBMED: | 21818113 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 3 January 2012" - "CODEN: LEUKE" - "Source: Scopus" |
