Identifying and addressing barriers to the delivery of optimal therapy for primary central nervous system lymphoma in the broader community Journal Article


Authors: Abrey, L. E.; Panageas, K. S.
Article Title: Identifying and addressing barriers to the delivery of optimal therapy for primary central nervous system lymphoma in the broader community
Abstract: Despite recent advances in the management of primary central nervous system lymphoma (PCNSL), recent population-based studies suggest that prognosis in the broader community has not improved substantially over the last 20 years. It is possible that this difference in outcome reflects a significant selection bias in the clinical series and trials reported. However, there is also preliminary evidence suggesting that patients in the community may not receive optimal management. There are many possible reasons that might account for disparities in care and outcome, but these have not been specifically addressed with regard to PCNSL. We have sought to elaborate some potential causes of these disparities; however, future studies are needed to identify and address specific barriers to care in the community.
Keywords: cancer survival; treatment outcome; aged; middle aged; survival rate; overall survival; prednisone; clinical trial; review; cancer recurrence; doxorubicin; cancer combination chemotherapy; drug efficacy; drug safety; primary central nervous system lymphoma; treatment; methotrexate; drug megadose; neurotoxicity; nuclear magnetic resonance imaging; brain neoplasms; antineoplastic agent; treatment indication; computer assisted tomography; cyclophosphamide; dexamethasone; vincristine; practice guideline; central nervous system neoplasms; outcome assessment (health care); medicare; survival time; population research; whole body radiation; public health service; lymphoma; medical oncology; primary cns lymphoma; social aspect; health care delivery; clinical trials; health care access; community care; health services accessibility; community health services
Journal Title: Leukemia and Lymphoma
Volume: 47
Issue: 12
ISSN: 1042-8194
Publisher: Taylor & Francis Group  
Date Published: 2006-12-01
Start Page: 2449
End Page: 2452
Language: English
DOI: 10.1080/10428190600881272
PUBMED: 17169791
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 3" - "Export Date: 4 June 2012" - "CODEN: LELYE" - "Source: Scopus"
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MSK Authors
  1. Lauren E Abrey
    270 Abrey
  2. Katherine S Panageas
    324 Panageas