Dipping into the cytosol to broaden the MHC class II peptide repertoire Journal Article
| Authors: | Denzin, L. K.; Sant'angelo, D. B. |
| Article Title: | Dipping into the cytosol to broaden the MHC class II peptide repertoire |
| Abstract: | A new study by Zhou et al. (2005) in this issue of Immunity explores how cytoplasmic autoantigens gain access to the MHC class II antigen-processing pathway. Their experiments show that hsc70 and Lamp-2a mediate antigen transport into endosomal compartments for presentation by MHC class II. Copyright ©2005 by Elsevier Inc. |
| Keywords: | signal transduction; nonhuman; antigen expression; t lymphocyte; protein degradation; protein protein interaction; antigen presentation; immune response; glutamate decarboxylase; major histocompatibility antigen class 2; peptides; autoantigens; short survey; electroporation; heat shock protein 70; antigens, cd; autophagy; histocompatibility antigens class ii; immunoglobulin kappa chain; cytosol; rna splicing; hsp70 heat-shock proteins; chaperone; cell surface; lysosome associated membrane protein 2; endosomes; hsc70 heat-shock proteins; lysosome-associated membrane glycoproteins |
| Journal Title: | Immunity |
| Volume: | 22 |
| Issue: | 5 |
| ISSN: | 1074-7613 |
| Publisher: | Cell Press |
| Date Published: | 2005-05-01 |
| Start Page: | 536 |
| End Page: | 537 |
| Language: | English |
| DOI: | 10.1016/j.immuni.2005.05.003 |
| PUBMED: | 15894271 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 24 October 2012" - "CODEN: IUNIE" - "Source: Scopus" |
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