Molecular mechanisms in hepatocellular carcinoma development Journal Article
| Authors: | Cha, C.; DeMatteo, R. P. |
| Article Title: | Molecular mechanisms in hepatocellular carcinoma development |
| Abstract: | Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. It usually develops in patients with chronic viral hepatitis, aflatoxin exposure, or excessive alcohol use. Most patients with HCC present with advanced disease and have a poor prognosis. The implementation of antiviral drugs and the availability of a vaccine for hepatitis B should help reduce the incidence of HCC. Considerable effort has now focused on unraveling the molecular pathogenesis of HCC in order to design better treatments, or to prevent the disease altogether. However, so far, the pathogenesis of HCC appears to be quite heterogenous among patients. In particular, several mechanisms of tumorigenesis seem to be involved, including loss of tumor suppressor gene function, oncogene activation, direct viral effects, DNA methylation, and angiogenesis. It is not clear which events are critical in tumor initiation versus tumor progression. RNA expression arrays and proteomics hold promise to provide further clues about this common and complex cancer. © 2004 Elsevier Ltd. All rights reserved. |
| Keywords: | pathogenesis; review; cirrhosis; hepatocellular carcinoma; advanced cancer; cancer growth; hepatitis b; liver cell carcinoma; carcinoma, hepatocellular; liver neoplasms; cancer incidence; cancer prevention; gene expression; gene function; angiogenesis; proteomics; dna methylation; oncogenes; rna; gene expression regulation; oncogene; tumor suppressor gene; gene activation; alcohol; dna, viral; antivirus agent; dna mutational analysis; tumor suppressor genes; loss of heterozygosity; hepatitis b virus; hepatitis c virus; virus hepatitis; hepatitis b vaccine; genes, tumor suppressor; p53; molecular; liver carcinogenesis; aflatoxin |
| Journal Title: | Best Practice & Research: Clinical Gastroenterology |
| Volume: | 19 |
| Issue: | 1 |
| ISSN: | 1521-6918 |
| Publisher: | Elsevier Ltd |
| Date Published: | 2005-02-01 |
| Start Page: | 25 |
| End Page: | 37 |
| Language: | English |
| DOI: | 10.1016/j.bpg.2004.11.005 |
| PUBMED: | 15757803 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 43" - "Export Date: 24 October 2012" - "CODEN: BPRCB" - "Source: Scopus" |
