Hepatocellular carcinoma: Consensus recommendations of the National Cancer Institute clinical trials planning meeting Journal Article


Authors: Thomas, M. B.; Jaffe, D.; Choti, M. M.; Belghiti, J.; Curley, S.; Fong, Y. M.; Gores, G.; Kerlan, R.; Merle, P.; O'Neil, B.; Poon, R.; Schwartz, L.; Tepper, J.; Yao, F.; Haller, D.; Mooney, M.; Venook, A.
Article Title: Hepatocellular carcinoma: Consensus recommendations of the National Cancer Institute clinical trials planning meeting
Abstract: Hepatocelluar carcinoma (HCC) is the most common primary malignancy of the liver in adults and the third most common cause of cancer death worldwide. The incidence of HCC in the United States is rising steadily because of the prevalence of hepatitis C viral infection and other causes of hepatic cirrhosis. The majority of patients have underlying hepatic dysfunction, which complicates patient management and the search for safe and effective therapies. The Clinical Trials Planning Meeting (CTPM) in HCC was convened by the National Cancer Institute's Gastrointestinal Cancer Steering Committee to identify the key knowledge gaps in HCC and define clinical research priorities. The CTPM structured its review according to current evidence-based treatment modalities in HCC and prioritized the recommendations on the basis of the patient populations representing the greatest unmet medical need.
Keywords: long-term survival; phase-ii trial; randomized controlled-trial; endothelial growth-factor; transcatheter; arterial chemoembolization; activated protein-kinases; multidetector-row ct; primary liver-cancer; chronic hepatitis-c; disease meld score
Journal Title: Journal of Clinical Oncology
Volume: 28
Issue: 25
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 2010-09-01
Start Page: 3994
End Page: 4005
Language: English
ACCESSION: ISI:000281502500017
DOI: 10.1200/jco.2010.28.7805
PROVIDER: wos
PMCID: PMC2940397
PUBMED: 20679622
Notes: --- - Article - "Source: Wos"
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MSK Authors
  1. Lawrence H Schwartz
    275 Schwartz
  2. Yuman Fong
    729 Fong