Paired ductal lavage and fine-needle aspiration specimens from patients with breast carcinoma Journal Article

  

Authors:	Brogi, E.; Miller, M. J.; Casadio, C.; Ljung, B. M.; Montgomery, L.
Article Title:	Paired ductal lavage and fine-needle aspiration specimens from patients with breast carcinoma
Abstract:	Ductal lavage (DL) is a new procedure for sampling of the mammary epithelium, but experience with this technique remains limited. We compared the findings in paired DL and fine-needle aspiration (FNA) specimens obtained from patients with breast carcinoma. Four reviewers evaluated all DL samples. Two reviewers also examined the FNA material and compared cellular composition and morphologic findings in paired samples. DL and FNA samples from six patients were satisfactory for evaluation. Two DL samples showed marked atypia, one showed mild atypia, and two were benign; there was no agreement in one case (mild atypia vs. benign). Overall, the atypical cells in DL samples resembled those in the paired FNA material, but low degree of cytologic atypia and relative paucity of atypical cells limited their correct identification. The interpretation of DL samples is more challenging than that of FNA material, but similar criteria apply. To increase the sensitivity of DL, the number of epithelial cells required for a satisfactory sample should be higher than previously set. © 2005 Wiley-Liss, Inc.
Keywords:	clinical article; human cell; cancer grading; diagnostic accuracy; cytology; breast; mastectomy; breast neoplasms; risk assessment; cancer cytodiagnosis; breast carcinoma; biopsy, fine-needle; carcinoma; intraductal carcinoma; ductal carcinoma; aspiration cytology; irrigation
Journal Title:	Diagnostic Cytopathology
Volume:	33
Issue:	6
ISSN:	8755-1039
Publisher:	Wiley Liss
Date Published:	2005-12-01
Start Page:	370
End Page:	375
Language:	English
DOI:	10.1002/dc.20354
PUBMED:	16299749
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-28844438686&partnerID=40&md5=d429e58a4b76a49d2fe96817f3b64038
Notes:	--- - "Cited By (since 1996): 4" - "Export Date: 24 October 2012" - "CODEN: DICYE" - "Source: Scopus"

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