Analysis of cancers not diagnosed at stereotactic core breast biopsy Journal Article

Authors: Liberman, L.; Dershaw, D. D.; Glassman, J. R.; Abramson, A. F.; Morris, E. A.; LaTrenta, L. R.; Rosen, P. P.
Article Title: Analysis of cancers not diagnosed at stereotactic core breast biopsy
Abstract: PURPOSE: To evaluate the mammographic and histopathologic features of carcinomas not diagnosed at stereotactic core biopsy. MATERIALS AND METHODS: A retrospective review revealed 144 surgically confirmed carcinomas preoperatively sampled with stereotactic core biopsy. Diagnosis at stereotactic core biopsy was carcinoma in 116 (81%) lesions, atypical hyperplasia in 21 (15%), and benign findings discordant with those from mammography in seven (5%). Mammographic and histopathologic findings in the latter 28 cases were reviewed. RESULTS: Prompt repeat biopsy was recommended in all 28 cases. The frequency with which a cancer yielded atypical hyperplasia at stereotactic core biopsy was higher for calcifications than masses (30% vs 5%, P < .0001), ductal carcinoma in situ (DCIS) than infiltrating carcinoma (33% vs 7%, P = .0002), and noncomedo than comedo DCIS (60% vs 9%, P = .0008). No significant difference was observed in the likelihood of benign core biopsy findings without atypia in malignant calcifications versus masses (7% vs 3%, P = .43), DCIS versus infiltrating carcinoma (7% vs 4%, P = .43), or noncomedo versus comedo DCIS (0% vs 9%, P = .49). CONCLUSION: The likelihood of not diagnosing carcinoma was highest for calcifications and for noncomedo DCIS. Discordance in mammographic and histopathologic findings or the presence of atypical hyperplasia may enable the radiologist to identify missed or underestimated carcinomas prospectively and avoid a delay in diagnosis.
Keywords: adult; human tissue; aged; aged, 80 and over; middle aged; retrospective studies; major clinical study; histopathology; cancer diagnosis; breast cancer; breast; breast neoplasms; retrospective study; biopsy; mammography; carcinoma in situ; breast biopsy; carcinoma, ductal, breast; stereotaxic surgery; calcinosis; stereotaxic techniques; humans; human; female; priority journal; article; breast neoplasms, diagnosis; breast, biopsy
Journal Title: Radiology
Volume: 203
Issue: 1
ISSN: 0033-8419
Publisher: Radiological Society of North America, Inc.  
Date Published: 1997-04-01
Start Page: 151
End Page: 157
Language: English
PUBMED: 9122384
PROVIDER: scopus
DOI: 10.1148/radiology.203.1.9122384
Notes: Article -- Export Date: 17 March 2017 -- Source: Scopus
Altmetric Score
MSK Authors
  1. D David Dershaw
    177 Dershaw
  2. Laura Liberman
    169 Liberman
  3. Elizabeth A Morris
    249 Morris
  4. Paul P Rosen
    105 Rosen