| Abstract: |
Male breast masses are uncommon pathologic findings. They are rarely aspirated, resulting in limited cytopathologic experience. The following study describes the cytopathology of male breast lesions from data collected for a period of 10 yr from three large institutions. A total of 14,026 breast aspirations were performed of which 614 were from male patients. All cases were reviewed and correlated with the appropriate clinicopathologic follow-up. The FNA diagnoses were as follows: benign, 427 cases (gynecomastia 353, fat necrosis 21, miscellaneous 53); malignant, 32 cases (ductal carcinoma nos 15, metastatic tumors 17); and atypical/suspicious, 61 cases. Ninety-four cases were nondiagnostic due to scant cellularity. Male breast aspirates accounted for 4.3% of the total breast FNAs performed. The clinicopathologic follow-up in both the benign and malignant categories showed 100% correlation. The overall sensitivity was 95.3%, specificity was 100%, and diagnostic accuracy was 98%. A relatively high specimen unsatisfactory rate was seen (>15%). The commonest cytopathologic diagnosis was gynecomastia, followed by ductal carcinoma. Florid duct atypia in gynecomastia may mimic adenocarcinoma, necessitating a higher threshold for cytopathologic interpretation for malignancy in males. © 2002 Wiley-Liss, Inc. |
| Keywords: |
adolescent; adult; human tissue; aged; aged, 80 and over; middle aged; major clinical study; clinical trial; follow up; diagnostic accuracy; sensitivity and specificity; reproducibility of results; metastasis; biopsy, needle; multicenter study; breast tumor; breast carcinoma; carcinoma in situ; aspiration biopsy; gynecomastia; cytopathology; clinical examination; male breast; breast neoplasms, male; carcinoma, ductal, breast; fat necrosis; breast duct; fine needle aspiration; humans; human; male; priority journal; article
|
