Polycystins: Inhibiting the inhibitors Journal Article
| Author: | Benezra, R. |
| Article Title: | Polycystins: Inhibiting the inhibitors |
| Abstract: | Polycystin-1 and -2 - two integral membrane proteins that are mutated in polycystic kidney disease - regulate the cell cycle by preventing nuclear localization of the pro-proliferative helix-loop-helix (HLH) protein Id2. This novel mechanism for restraining Id proteins has important implications for our understanding of the nature of polycystic kidney disease and perhaps other proliferative disorders. ©2005 Nature Publishing Group. |
| Keywords: | signal transduction; gene mutation; nonhuman; note; pathophysiology; protein localization; cell proliferation; gene targeting; cell cycle; gene overexpression; carboxy terminal sequence; protein protein interaction; intracellular transport; genetic transcription; extracellular matrix; membrane protein; active transport, cell nucleus; cell nucleus; inhibitor of differentiation 2; cell interaction; beta catenin; kidney polycystic disease; membrane structure; helix loop helix protein; inhibitor of differentiation protein 2; polycystin 1; polycystin 2; trpp cation channels |
| Journal Title: | Nature Cell Biology |
| Volume: | 7 |
| Issue: | 12 |
| ISSN: | 1465-7392 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2005-12-01 |
| Start Page: | 1164 |
| End Page: | 1165 |
| Language: | English |
| DOI: | 10.1038/ncb1205-1164 |
| PUBMED: | 16319969 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 5" - "Export Date: 24 October 2012" - "CODEN: NCBIF" - "Source: Scopus" |
