Expression patterns of Id1, Id2, and Id3 are highly related but distinct from that of Id4 during mouse embryogenesis Journal Article

  


Authors: Jen, Y.; Manova, K.; Benezra, R.
Article Title: Expression patterns of Id1, Id2, and Id3 are highly related but distinct from that of Id4 during mouse embryogenesis
Abstract: The murine dominant negative helix-loop-helix (dnHLH) proteins inhibit the activities of bHLH transcription factors in diverse cell lineages (Benezra et al. [1990] Cell 61:49-59; Christy et al [1991] Proc. Natl. Acad. Sci. U.S.A. 88:1815-1819; Sun et al [1991] Mol. Cell Biol. 11: 5603-5611; Riechmann et al. [1994] Nucleic Acids Res. 22:749-755). Currently, there are four members in the dnHLH family, Id1, Id2, Id3, and Id4. In this report, we have performed a detailed comparative in situ hybridization analysis to examine their expression pattern during post-gastrulational mouse development. Id1, 2, and 3 are expressed in multiple tissues, whereas Id4 expression can only be detected in neuronal tissues and in the ventral portion of the epithelium of the developing stomach. The regions where Id1-3 genes are expressed, such as gut, lung, kidney, tooth, whisker, and several glandular structures, are undergoing active morphogenetic activities. The expression patterns of Id1, 2, and 3 overlap in many organs, except in the tissues derived from primitive gut. In the latter, Id1 and Id3 signals are detected in the mesenchyme surrounding the epithelium, whereas Id2 is expressed within the epithelium. The difference in the patterns of expressions of Id1-3 and Id4 suggest that the dominant negative transcriptional activity of these two subclasses of the Id family may have different physiological consequences.
Keywords: nonhuman; mouse; animals; mice; animal tissue; gene expression; embryo; embryo development; morphogenesis; animalia; in situ hybridization; kidney; lung; murinae; bone and bones; epithelium; mesoderm; nerve cell; heart; mesenchyme; myocardium; viscera; differentiation; gastrulation; cartilage; mouse embryogenesis; digestive system; helix loop helix protein; id; helix-loop-helix motifs; priority journal; article; helix-loop-helix; endocrine glands; exocrine glands
Journal Title: Developmental Dynamics
Volume: 207
Issue: 3
ISSN: 1058-8388
Publisher: Wiley Periodicals, Inc  
Date Published: 1996-11-01
Start Page: 235
End Page: 252
Language: English
DOI: 10.1002/(sici)1097-0177(199611)207:3<235::aid-aja1>3.0.co;2-i
PUBMED: 8922523
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029985185&doi=10.1002%2f%28SICI%291097-0177%28199611%29207%3a3%3c235%3a%3aAID-AJA1%3e3.0.CO%3b2-I&partnerID=40&md5=066b38f479e85854cd1b328c8fefae6b
Notes: Article -- Export Date: 22 November 2017 -- Source: Scopus
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MSK Authors
  1. Robert Benezra
    146 Benezra
  2. Katia O Manova-Todorova
    161 Manova-Todorova
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