Id proteins in development, cell cycle and cancer Journal Article
| Authors: | Ruzinova, M. B.; Benezra, R. |
| Article Title: | Id proteins in development, cell cycle and cancer |
| Abstract: | Id proteins are important parts of signaling pathways involved in development, cell cycle and tumorigenesis. They were first shown to act as dominant negative antagonists of the basic helix-loop-helix family of transcription factors, which positively regulate differentiation in many cell lineages. The Id proteins do this by associating with the ubiquitous E proteins and preventing them from binding DNA or other transcription factors. Id proteins also associate with Ets transcription factors and the Rb family of tumor suppressor proteins, and are downstream targets of transforming growth factor β and bone morphogenic protein signaling. Thus, the Id proteins have become important molecules for understanding basic biological processes as well as targets for potential therapeutic intervention in human disease. |
| Keywords: | signal transduction; protein expression; unclassified drug; promoter region; sequence analysis; review; cytotoxic agent; nonhuman; disease marker; cancer grading; protein function; neoplasms; t lymphocyte; cytology; animals; mice; mice, knockout; gene targeting; cell cycle; gene overexpression; apoptosis; immune system; breast cancer; models, biological; transforming growth factor beta; protein; transcription factor; morphogenesis; cell differentiation; b lymphocyte; cell lineage; transcription factors; stem cell; ewing sarcoma; endothelium cell; gene expression regulation; correlation analysis; neuroblastoma; protein synthesis; prostate tumor; tumor cell; cell migration; aging; upregulation; inhibitor of differentiation protein 1; protein family; dna binding; tumor suppressor protein; neovascularization, physiologic; retinoblastoma protein; repressor proteins; drug sensitivity; oncogene c myb; neovascularization (pathology); amino acid motifs; downstream processing; bone morphogenetic proteins; thyroid medullary carcinoma; inhibitor of differentiation protein; helix-loop-helix motifs; humans; human; priority journal; e protein |
| Journal Title: | Trends in Cell Biology |
| Volume: | 13 |
| Issue: | 8 |
| ISSN: | 0962-8924 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2003-08-01 |
| Start Page: | 410 |
| End Page: | 418 |
| Language: | English |
| DOI: | 10.1016/s0962-8924(03)00147-8 |
| PUBMED: | 12888293 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
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