Necrotizing vasculopathy of the CNS: Case report Journal Article

  


Authors: Begemann, M.; Krol, G.; Rosenblum, M. K.; De Angelis, L. M.
Article Title: Necrotizing vasculopathy of the CNS: Case report
Abstract: A 62-year-old man with progressive cerebellar and brainstem dysfunction had gadolinium-enhancing lesions in basal ganglia and occipital lobe on MRI suggestive of primary CNS lymphoma (PCNSL). The patient, who had been treated with high-dose steroid hormones for several months, developed respiratory failure and expired before a histological diagnosis could be obtained. The postmortem examination showed Pneumocystis carinii was the cause of death. Pathology of the brain showed a necrotizing vasculopathy affecting the white matter of the cerebrum and cerebellum with involvement of the basal ganglia and the periventricular gray matter. Other organs such as liver, lung, and kidneys were spared. Necrotizing vasculopathy is a novel entity that should be considered in the differential diagnosis of PCNSL. © Springer 2005.
Keywords: adult; middle aged; case report; primary central nervous system lymphoma; gadolinium; drug megadose; nuclear magnetic resonance imaging; brain neoplasms; magnetic resonance imaging; diagnosis, differential; differential diagnosis; steroid; pneumocystis pneumonia; necrosis; cause of death; liver; kidney; contrast enhancement; lymphoma; lung; autopsy; primary cns lymphoma; fatal outcome; vasculopathy; ataxia; brain stem; white matter; respiratory failure; ptosis; nystagmus; saccadic eye movement; vasculitis; occipital lobe; pneumocystis infections; pneumocystis carinii; basal ganglion; cerebellum disease; periaqueductal gray matter; babinski reflex; pneumocystis carini pneumonia; epidermolysis bullosa acquisita; necrotizing arteritis; pneumonia, pneumocystis
Journal Title: Journal of Neuro-Oncology
Volume: 72
Issue: 2
ISSN: 0167-594X
Publisher: Springer  
Date Published: 2005-04-01
Start Page: 191
End Page: 193
Language: English
DOI: 10.1007/s11060-004-2063-x
PUBMED: 15926001
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-20444390144&partnerID=40&md5=16fbc0b4e6d229182d5f2d51859975d1
Notes: --- - "Export Date: 24 October 2012" - "CODEN: JNODD" - "Source: Scopus"
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MSK Authors
  1. Lisa De Angelis
    576 De Angelis
  2. Marc Rosenblum
    424 Rosenblum
  3. Martin Begemann
    5 Begemann
  4. George Krol
    86 Krol
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