HIV antigen in the brains of patients with the AIDS dementia complex Journal Article
| Authors: | Pumarola‐Sune, T.; Navia, B. A.; Cordon‐Cardo, C.; Cho, E. ‐S; Price, R. W. |
| Article Title: | HIV antigen in the brains of patients with the AIDS dementia complex |
| Abstract: | Human immunodeficiency virus infection was identified immunohistochemically in the brains of 8 patients with acquired immune deficiency syndrome dementia complex. Using a monoclonal antibody against a structural viral protein (p25), infection was detected in white matter and basal ganglia in a distribution paralleling that of the major neuropathological abnormalities. Viral antigen was identified principally in perivascular and parenchymal macrophages and in multinucleated cells of macrophage origin that were identified morphologically and by immunocytochemical staining for acid phsophatase isozyme. In 4 of the 8 patients, viral antigen was also detected in acid‐phosphatase–negative, process‐bearing neuroglial cells; in 2 patients, antigen was detected in basal ganglion cells that were morphologically consistent with neurons and in alkaline‐phosphatase–positive cells with elongated nuclei that were most likely of endothelial origin. Copyright © 1987 American Neurological Association |
| Keywords: | immunohistochemistry; adult; child, preschool; middle aged; case report; neurons; histology; central nervous system; monoclonal antibody; immunoenzyme techniques; antibodies, monoclonal; antigen; brain; diagnosis; dementia; neuroglia; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; autopsy; cerebral cortex; macrophages; antigens, viral; basal ganglia; humans; human; male; female; priority journal; hiv antigens |
| Journal Title: | Annals of Neurology |
| Volume: | 21 |
| Issue: | 5 |
| ISSN: | 0364-5134 |
| Publisher: | Wiley Blackwell |
| Date Published: | 1987-05-01 |
| Start Page: | 490 |
| End Page: | 496 |
| Language: | English |
| DOI: | 10.1002/ana.410210513 |
| PUBMED: | 3296948 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus; Acknowledgements: We thank Drs Lynn Goldstein and Kathy Shiver of Genetic Systems Corporation, Seattle, WA, for the monoclonal antibody; Drs George W. Shaw, Charles S. Cobbs, and Beatrice H. Hahn of the University of Alabama, Birmngham, for assessment of our patients by Southern blot hybridization; Atia Khan for expert technical assistance; Dr Carol K. Petito of The New York Hospital-Cornell University Medical Center for providing material from two of the patients included in this study and for helpful discussion; and Adele Ahronheim for preparation of this manuscript |
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