Microglia in the giant cell encephalitis of acquired immune deficiency syndrome: proliferation, infection and fusion Journal Article
| Authors: | Michaels, J.; Price, R. W.; Rosenblum, M. K. |
| Article Title: | Microglia in the giant cell encephalitis of acquired immune deficiency syndrome: proliferation, infection and fusion |
| Abstract: | The autopsied brains of three homosexual men with acquired immune deficiency syndrome (AIDS), progressive encephalopathy and widespread multinucleated giant cell encephalitis were investigated by lectin and immunohistochemical methods to ascertain the cellular distribution of a human immunodeficiency virus (HIV) core protein, p25. Abundant viral antigen was present in all brains, limited to perivascular macrophages, microglial and multinucleated cells, some bearing elongated cytoplasmic processes. The multinucleated cells were consistently labelled by the lectin Ricinus communis agglutinin-1, a marker for microglia, which demonstrated processbearing variants of these cells. The prominent staining of microglia for viral antigen and the morphological suggestion that they fuse with other microglia and/or macrophages to form the multinucleated cells characteristic of HIV encephalitis indicate that microglia are probably direct targets of HIV infection and serve to propagate and amplify this retroviral encephalitis. © 1988 Springer-Verlag. |
| Keywords: | adult; aged; case report; histology; neuroglia; homosexuality; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; autopsy; encephalitis; hiv; middle age; microglia; aids; ricin; human; male; priority journal; hiv antigens; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; viral core proteins; hiv encephalitis |
| Journal Title: | Acta Neuropathologica |
| Volume: | 76 |
| Issue: | 4 |
| ISSN: | 0001-6322 |
| Publisher: | Springer |
| Date Published: | 1988-07-01 |
| Start Page: | 373 |
| End Page: | 379 |
| Language: | English |
| DOI: | 10.1007/bf00686974 |
| PUBMED: | 3176903 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 6 August 2020 -- Source: Scopus |
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