Patient online self-reporting of toxicity symptoms during chemotherapy Journal Article


Authors: Basch, E.; Artz, D.; Dulko, D.; Scher, K.; Sabbatini, P.; Hensley, M.; Mitra, N.; Speakman, J.; McCabe, M.; Schrag, D.
Article Title: Patient online self-reporting of toxicity symptoms during chemotherapy
Abstract: Purpose: Tracking symptoms related to treatment toxicity is standard practice in routine care and during clinical trials. Currently, clinicians collect symptom information via complex and often inefficient mechanisms, but there is growing interest in collecting outcome information directly from patients. Patients and Methods: The National Cancer Institute Common Terminology Criteria for Adverse Events schema for seven common symptoms was adapted into a Web-based patient-reporting system, accessible from desktop computers in outpatient clinics and from home computers. Eighty patients with gynecologic malignancies beginning standard chemotherapy regimens were enrolled between April and September 2004. During an 8-week observation period, participants were encouraged to log in and report symptoms at each follow-up visit, or alternatively, to access the system from home. Results: All patients completed an initial log in. At each subsequent appointment, most enrollees (80% to 85%) reported symptoms using the online system, with a mean of three follow-up visits per patient during the observation period (range, one to six). Sixty of 80 patients (75%) logged in at least once from home. Use was significantly associated with prior Internet experience. Forty-two severe toxicities (grade 3 to 4) entered from home prompted seven clinician interventions. Most patients (96%) found the system useful and would recommend it to others. Conclusion: Patients are capable of reporting symptoms experienced during chemotherapy using a Web-based interface. Assessment in the clinical trial setting and comparison of direct patient-versus clinician-based approaches for reporting symptoms and their severity are warranted. © 2005 by American Society of Clinical Oncology.
Keywords: adolescent; adult; cancer chemotherapy; aged; middle aged; major clinical study; constipation; fatigue; diarrhea; united states; comparative study; follow up; antineoplastic agent; sensitivity and specificity; anorexia; pain; cohort studies; nausea; vomiting; antineoplastic combined chemotherapy protocols; cohort analysis; internet; patient monitoring; pathology; self report; genital neoplasms, female; patient participation; drug surveillance program; adverse drug reaction reporting systems; feasibility study; feasibility studies; outpatient; drug toxicity; home care; gynecologic cancer; online systems; female genital tract tumor; online system
Journal Title: Journal of Clinical Oncology
Volume: 23
Issue: 15
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 2005-05-20
Start Page: 3552
End Page: 3561
Language: English
DOI: 10.1200/jco.2005.04.275
PUBMED: 15908666
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 63" - "Export Date: 24 October 2012" - "CODEN: JCOND" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Nandita Mitra
    22 Mitra
  2. Ethan Martin Basch
    156 Basch
  3. Dorothy Dulko
    13 Dulko
  4. Deborah Schrag
    137 Schrag
  5. Paul J Sabbatini
    199 Sabbatini
  6. Martee L Hensley
    220 Hensley
  7. Mary McCabe
    93 McCabe
  8. David R Artz
    10 Artz
  9. Kevin S Scher
    2 Scher