Long-term toxicity monitoring via electronic patient-reported outcomes in patients receiving chemotherapy Journal Article


Authors: Basch, E.; Iasonos, A.; Barz, A.; Culkin, A.; Kris, M. G.; Artz, D.; Fearn, P.; Speakman, J.; Farquhar, R.; Scher, H. I.; McCabe, M.; Schrag, D.
Article Title: Long-term toxicity monitoring via electronic patient-reported outcomes in patients receiving chemotherapy
Abstract: Purpose: In cancer treatment trials, clinicians traditionally report patient toxicity symptoms. Alternatively, patients could provide this information directly. Patients and Methods: The Common Terminology Criteria for Adverse Events (CTCAE) is the mandated instrument for tracking patient toxicity symptoms in National Cancer Institute (NCI)-sponsored cancer treatment trials. We adapted CTCAE symptom items into patient language and uploaded these to an online platform. Lung cancer outpatients receiving chemotherapy were invited to self-report selected symptoms at visits via waiting area computers or optional home access. Symptom reports were printed for nurses at visits, but no instructions were given with regard to use of this information. Results: From June 2005 through March 2006, 125 patients were invited to participate, and 107 chose to enroll. Mean length of participation was 42 weeks (range, 1 to 71 weeks), by which time 35% died. The average number of clinic visits was 12 (range, 1 to 40 visits). At each consecutive visit, most patients (mean, 78%) logged in without significant attrition. Reasons for failure to log in included having no reminder and having inadequate time. Although 76% of enrollees had home computers, only 15% self-reported from home. Satisfaction with the system was high (90%), but only 51% felt communication was improved. All participating nurses understood the reports and felt this information was useful for clinical decisions, documentation, and discussions. However, only one of seven nurses discussed reports with patients frequently, with insufficient time being the most common barrier to discussions. Conclusion: Online patient self-reporting is a feasible long-term strategy for toxicity symptom monitoring during chemotherapy, even among patients with advanced cancer and high symptom burdens. However, without explicit reminders and clinician feedback, patients demonstrated limited voluntary interest in self-reporting between visits. © 2007 by American Society of Clinical Oncology.
Keywords: adult; cancer chemotherapy; controlled study; treatment outcome; aged; middle aged; patient satisfaction; major clinical study; clinical feature; constipation; cytotoxic agent; diarrhea; unspecified side effect; antineoplastic agents; outcome assessment; follow up; antineoplastic agent; anorexia; pain; nausea; vomiting; lung neoplasms; health survey; lung cancer; patient monitoring; self report; outcome assessment (health care); questionnaires; dyspnea; drug surveillance program; adverse drug reaction reporting systems; feasibility studies; patient compliance; outpatient; clinical decision making; health care organization; online systems
Journal Title: Journal of Clinical Oncology
Volume: 25
Issue: 34
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 2007-12-01
Start Page: 5374
End Page: 5380
Language: English
DOI: 10.1200/jco.2007.11.2243
PUBMED: 18048818
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 28" - "Export Date: 17 November 2011" - "CODEN: JCOND" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Ethan Martin Basch
    156 Basch
  2. Deborah Schrag
    137 Schrag
  3. Allison Barz
    11 Barz
  4. Alexia Elia Iasonos
    179 Iasonos
  5. Howard Scher
    817 Scher
  6. Mark Kris
    597 Kris
  7. Ann E Culkin
    14 Culkin
  8. Paul A Fearn
    58 Fearn
  9. Mary McCabe
    93 McCabe
  10. David R Artz
    10 Artz