Personalized medicine for non-small-cell lung cancer: Implications of recent advances in tissue acquisition for molecular and histologic testing Journal Article

  


Authors: Moreira, A. L.; Thornton, R. H.
Article Title: Personalized medicine for non-small-cell lung cancer: Implications of recent advances in tissue acquisition for molecular and histologic testing
Abstract: In light of recent advances in individualized therapy for Non-Small-cell lung cancer (NSCLC), molecular and histologic profiling is essential for guiding therapeutic decisions. Results of these analyses may have implications for both response (eg, molecular testing for EGFR [epidermal growth factor receptor] mutations) and safety (eg, contraindications for squamous histology) in NSCLC. Most patients with NSCLC present with unresectable advanced disease; therefore, greater emphasis is being placed on minimally invasive tissue acquisition techniques, such as small biopsy and cytology specimens. Due to the need for increasing histologic and molecular information and increasingly smaller tissue sample sizes, efforts must be focused on optimizing tissue acquisition and the development of more sensitive molecular assays. Recent advances in tissue acquisition techniques and specimen preservation may help to address this challenge and lead to enhanced personalized treatment in NSCLC. © 2012 Elsevier Inc.
Keywords: immunohistochemistry; gene mutation; histopathology; review; squamous cell carcinoma; erlotinib; advanced cancer; polymerase chain reaction; adenocarcinoma; lung non small cell cancer; carcinoma, non-small-cell lung; lung neoplasms; clinical assessment; lung cancer; food and drug administration; biopsy; histology; docetaxel; specimen handling; gefitinib; pleura effusion; oncogene k ras; pemetrexed; molecular diagnosis; individualized medicine; transthoracic aspiration; endobronchial ultrasonography; crizotinib; transbronchial aspiration; afatinib; dacomitinib; tissue procurement; tissue and organ procurement
Journal Title: Clinical Lung Cancer
Volume: 13
Issue: 5
ISSN: 1525-7304
Publisher: Elsevier Inc.  
Date Published: 2012-09-01
Start Page: 334
End Page: 339
Language: English
DOI: 10.1016/j.cllc.2012.01.004
PROVIDER: scopus
PUBMED: 22424871
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84865467600&partnerID=40&md5=559b93c909bda928eacdef6f74ae1b5a
Notes: --- - "Export Date: 1 October 2012" - "CODEN: CLCLC" - "Source: Scopus"
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MSK Authors
  1. Andre L Moreira
    176 Moreira
  2. Raymond H Thornton
    84 Thornton
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