Histologic considerations for individualized systemic therapy approaches for the management of non-small cell lung cancer Journal Article
| Authors: | West, H.; Harpole, D.; Travis, W. |
| Article Title: | Histologic considerations for individualized systemic therapy approaches for the management of non-small cell lung cancer |
| Abstract: | Over the past 5 to 10 years, we have reached a treatment plateau using standard platinum-based doublets in an unselected population of patients with advanced non-small cell lung cancer (NSCLC). Recent studies have focused on improving patient outcomes with new chemotherapeutic or targeted agents, as well as on individualizing therapy on the basis of patient characteristics such as tumor histology and biomarker analysis. This article summarizes recent data on histologic response determinants to chemotherapy and targeted therapy, with particular attention to the importance of standardized tissue collection, handling, storage, and analysis techniques, in order to best apply the results of tumor analysis to patient-care decisions. Such decisions are related to both improving patient safety and optimizing efficacy with standard chemotherapy as well as newer targeted therapy agents. This entails a change from a generalized approach in treating patients with NSCLC to an individualized strategy based on tumor histology. © 2009 American College of Chest Physicians. |
| Keywords: | immunohistochemistry; cancer survival; treatment outcome; clinical trial; review; sorafenib; bevacizumab; cisplatin; erlotinib; sunitinib; advanced cancer; cancer combination chemotherapy; drug efficacy; systemic therapy; antineoplastic agents; gemcitabine; paclitaxel; cancer patient; drug megadose; medical decision making; biological marker; carboplatin; low drug dose; progression free survival; multiple cycle treatment; bleeding; lung non small cell cancer; carcinoma, non-small-cell lung; lung neoplasms; analytic method; proteomics; histology; docetaxel; drug fatality; antibodies, monoclonal; lung adenocarcinoma; fluorescence in situ hybridization; specimen handling; patient safety; gefitinib; genomics; lung alveolus cell carcinoma; platinum derivative; large cell carcinoma; angiogenesis inhibitors; pemetrexed; tissue fixation; hemoptysis; lung hemorrhage; storage |
| Journal Title: | Chest |
| Volume: | 136 |
| Issue: | 4 |
| ISSN: | 0012-3692 |
| Publisher: | American College of Chest Physicians |
| Date Published: | 2009-10-01 |
| Start Page: | 1112 |
| End Page: | 1118 |
| Language: | English |
| DOI: | 10.1378/chest.08-2484 |
| PUBMED: | 19809052 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 4" - "Export Date: 30 November 2010" - "CODEN: CHETB" - "Source: Scopus" |
