Pathological diagnosis and classification of lung cancer in small biopsies and cytology: Strategic management of tissue for molecular testing Journal Article
| Authors: | Travis, W. D.; Rekhtman, N. |
| Article Title: | Pathological diagnosis and classification of lung cancer in small biopsies and cytology: Strategic management of tissue for molecular testing |
| Abstract: | Standardized lung cancer classifications by the World Health Organization have traditionally been based on the histological characteristics of resected tumors with little guidance about diagnosis based on small biopsies and cytology. The focus has mainly been on the separation of small-cell lung carcinoma (SCLC) and non-small-cell lung carcinoma (NSCLC). Until recently there have been no therapeutic implications to further classification of NSCLC, so little attention has historically been given to the distinction of adenocarcinoma and squamous cell carcinoma in these small tissue samples. This situation has changed dramatically in recent years with the discovery of several therapeutic options that are only available to patients with adenocarcinoma or NSCLC, not otherwise specified (NSCLC-NOS), rather than squamous cell carcinoma. Therefore this article reviews new criteria and terminology recently proposed by the new International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) lung adenocarcinoma classification. This includes recommendation for use of special stains as an aid to diagnosis, particularly in the setting of poorly differentiated tumors that do not show clear differentiation by light microscopy. The need for every institution to develop a multidisciplinary strategy to obtain these small specimens and process them not only for diagnosis but also for molecular testing is emphasized. © Georg Thieme Verlag KG Stuttgart. New York. |
| Keywords: | immunohistochemistry; human tissue; gene mutation; histopathology; microscopy; squamous cell carcinoma; cancer diagnosis; adenocarcinoma; cytology; lung non small cell cancer; lung cancer; tumor marker; histology; protein tyrosine kinase inhibitor; neuroendocrine tumor; lung small cell cancer; lung adenocarcinoma; ttf-1; sarcomatoid carcinoma; lung alveolus cell carcinoma; world health organization; adenosquamous carcinoma; lung squamous cell carcinoma; clear cell carcinoma; cancer classification; papillary carcinoma; aspiration biopsy; k ras protein; acinar cell carcinoma; chromogranin; lung biopsy; signet ring carcinoma; cancer morphology; mucinous carcinoma; p63; synaptophysin; egfr mutation; molecular diagnosis; 3 [1 (2,6 dichloro 3 fluorophenyl)ethoxy] 5 [1 (4 piperidinyl) 1h pyrazol 4 yl] 2 pyridinylamine; kras mutation; cd56 antigen; molecular testing; mucin stain; non-small-cell carcinoma; fetal adenocarcinoma; solid adenocarcinoma |
| Journal Title: | Seminars in Respiratory and Critical Care Medicine |
| Volume: | 32 |
| Issue: | 1 |
| ISSN: | 1069-3424 |
| Publisher: | Thieme Publishing |
| Date Published: | 2011-02-01 |
| Start Page: | 22 |
| End Page: | 31 |
| Language: | English |
| DOI: | 10.1055/s-0031-1272866 |
| PROVIDER: | scopus |
| PUBMED: | 21500121 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "CODEN: SRCCE" - "Source: Scopus" |
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