Embryonic stem cell miRNAs and their roles in development and disease Journal Article
| Authors: | Vidigal, J. A.; Ventura, A. |
| Article Title: | Embryonic stem cell miRNAs and their roles in development and disease |
| Abstract: | MicroRNAs have emerged as important modulators of gene expression. Both during development and disease, regulation by miRNAs controls the choice between self-renewal and differentiation, survival and apoptosis and dictates how cells respond to external stimuli. In mouse pluripotent embryonic stem cells, a surprisingly small set of miRNAs, encoded by four polycistronic genes is at the center of such decisions. miR-290-295, miR-302-367, miR-17-92 and miR-106b-25 encode for miRNAs with highly related sequences that seem to control largely overlapping gene sets. Recent studies have highlighted the importance of these miRNAs in the maintenance of 'stemness' and regulation of normal development and have linked the deregulation of their expression to a variety of human diseases. © 2012 Elsevier Ltd. |
| Keywords: | unclassified drug; review; nonhuman; neoplasms; mouse; animals; cell survival; apoptosis; microrna; embryonic stem cell; embryo development; cell renewal; cell differentiation; gene expression regulation; cell transformation; gene repression; stem cells; embryonic stem cells; 3' untranslated region; pluripotent stem cell; tumor growth; micrornas; cell cycle regulation; octamer transcription factor 4; cell cycle g1 phase; protein p130; embryonic development; cyclin e; biogenesis; dicer; argonaute 2 protein; cyclin dependent kinase 2; esc; mirna clusters; microrna 106b-25; microrna 17-92; microrna 290-295; microrna 302-367; self renewal |
| Journal Title: | Seminars in Cancer Biology |
| Volume: | 22 |
| Issue: | 5-6 |
| ISSN: | 1044-579X |
| Publisher: | Academic Press Inc., Elsevier Science |
| Date Published: | 2012-10-01 |
| Start Page: | 428 |
| End Page: | 436 |
| Language: | English |
| DOI: | 10.1016/j.semcancer.2012.04.009 |
| PROVIDER: | scopus |
| PMCID: | PMC3426648 |
| PUBMED: | 22561239 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 October 2012" - "CODEN: SECBE" - "Source: Scopus" |
