BCL6 positively regulates AID and germinal center gene expression via repression of miR-155 Journal Article
| Authors: | Basso, K.; Schneider, C.; Shen, Q.; Holmes, A. B.; Setty, M.; Leslie, C.; Riccardo, D. F. |
| Article Title: | BCL6 positively regulates AID and germinal center gene expression via repression of miR-155 |
| Abstract: | the BCL6 proto-oncogene encodes a transcriptional repressor that is required for germinal center (GC) formation and whose de-regulation is involved in lymphomagenesis. Although substantial evidence indicates that BCL6 exerts its function by repressing the transcription of hundreds of protein-coding genes, its potential role in regulating gene expression via microRNAs (miRNAs) is not known. We have identified a core of 15 miRNAs that show binding of BCL6 in their genomic loci and are down-regulated in GC B cells.Among BCL6 validated targets, miR-155 and miR-361 directly modulate AID expression, indicating that via repression of these miRNAs, BCL6 up-regulates AID. Similarly, the expression of additional genes relevant for the GC phenotype, including SPI1, IRF8, and MY,appears to be sustained via BCL6-mediated repression of miR-155. These findings identify a novel mechanism by which BCL6, in addition to repressing protein coding genes, promotes the expression of important GC functions by repressing specific miRNAs. © 2012 Basso et al. |
| Journal Title: | Journal of Experimental Medicine |
| Volume: | 209 |
| Issue: | 13 |
| ISSN: | 0022-1007 |
| Publisher: | Rockefeller University Press |
| Date Published: | 2012-12-17 |
| Start Page: | 2455 |
| End Page: | 2465 |
| Language: | English |
| DOI: | 10.1084/jem.20121387 |
| PROVIDER: | scopus |
| PMCID: | PMC3526356 |
| PUBMED: | 23166356 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 February 2013" - "CODEN: JEMEA" - "Source: Scopus" |
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