The MicroRNA-17-92 family of MicroRNA clusters in development and disease Journal Article
| Authors: | Concepcion, C. P.; Bonetti, C.; Ventura, A. |
| Article Title: | The MicroRNA-17-92 family of MicroRNA clusters in development and disease |
| Abstract: | Overwhelming experimental evidence accumulated over the past decade indicates that microRNAs (miRNAs) are key regulators of gene expression in animals and plants and play important roles in development, homeostasis, and disease.The miR-17-92 family of miRNA clusters is composed of 3 related, highly conserved, polycistronic miRNA genes that collectively encode for a total of 15 miRNAs. We discuss recent studies demonstrating that these miRNAs are essential for vertebrate development and homeostasis. We also show how their mutation or deregulation contributes to the pathogenesis of a variety of human diseases, including cancer and congenital developmental defects. Finally, we discuss the current evidence suggesting how the different miRNAs encoded by these 3 clusters can functionally cooperate to fine-tune signaling and developmental pathways. Copyright © 2012 by Lippincott Williams & Wilkins. |
| Keywords: | signal transduction; protein expression; unclassified drug; gene sequence; pathogenesis; review; nonhuman; neoplasm; neoplasms; animals; stat3 protein; apoptosis; microrna; gene expression; transforming growth factor beta; transcription, genetic; carcinogenesis; cell transformation, neoplastic; oncogenes; gene expression regulation; oncogene; b cell lymphoma; t cell lymphoma; myc protein; medulloblastoma; prostatic intraepithelial neoplasia; prostate hypertrophy; caenorhabditis elegans; drosophila melanogaster; bone development; developmental disorder; micrornas; oncogene c myc; vertebrates; t cell leukemia; transcription factor e2f1; transcription factor e2f2; protein patched 1; autosomal dominant disorder; biogenesis; rna processing, post-transcriptional; knockout gene; multigene family; transcription factor e2f3; haploinsufficiency; microrna 17 92; microrna clusters; mir-17-92 family; microrna 17; microrna 20a; microrna 19b 1; microrna 106a 25; microrna 106b 25; microrna 18a; microrna 19a; microrna 92; microrna 92a; feingold syndrome |
| Journal Title: | The Cancer Journal |
| Volume: | 18 |
| Issue: | 3 |
| ISSN: | 1528-9117 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2012-05-01 |
| Start Page: | 262 |
| End Page: | 267 |
| Language: | English |
| DOI: | 10.1097/PPO.0b013e318258b60a |
| PROVIDER: | scopus |
| PUBMED: | 22647363 |
| PMCID: | PMC3592780 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 July 2012" - "CODEN: CAJOC" - "Source: Scopus" |
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