PET of hypoxia: Current and future perspectives Journal Article
| Authors: | Carlin, S.; Humm, J. L. |
| Article Title: | PET of hypoxia: Current and future perspectives |
| Abstract: | In the past 25 y, a large amount of clinical experience with hypoxia PET tracers has accumulated. This article discusses recent improvements in image acquisition protocols and tracer pharmacology that have resulted in improved understanding of the underlying physiologic processes. The widespread clinical adoption of hypoxia PET tracers will depend largely on their utility in treatment prescription and in outcome monitoring. The establishment and validation of hypoxia-directed treatment protocols are still under development, and it is envisaged that the design and use of future hypoxia PET tracers will develop as part of this process. Copyright © 2012 by the Society of Nuclear Medicine and Molecular Imaging, Inc. |
| Keywords: | immunohistochemistry; unclassified drug; histopathology; review; solid tumor; treatment planning; cancer radiotherapy; outcome assessment; positron emission tomography; treatment indication; image analysis; clinical protocol; hypoxia; head and neck cancer; fluorodeoxyglucose f 18; computer assisted emission tomography; positron-emission tomography; radiopharmaceutical agent; drug clearance; 1 fluoro 3 (2 nitro 1 imidazolyl) 2 propanol f 18; radioactive tracers; image processing; pet; oxygen consumption; triazoles; anoxia; tumor hypoxia; nitroimidazoles; 2 (2 nitro 1h imidazol 1 yl) n (2,2,3,3,3 pentafluoropropyl)acetamide; etanidazole; hydrocarbons, fluorinated; cancer prognosis; ; 2?-nitroimidazole; 2 (2 nitro 1h imidazol 1 yl) n (2,2,3,3,3 pentafluoropropyl)acetamide f 18; 3 fluoro 2 [4 [(2 nitro 1h imidazol 1 yl)methyl] 1h 1,2,3 triazol 1 yl]propan 1 ol f 18; fluoroazomycinarabinofuranoside f 18; fluoroerythronitromidazole f 18; hx 4 |
| Journal Title: | Journal of Nuclear Medicine |
| Volume: | 53 |
| Issue: | 8 |
| ISSN: | 0161-5505 |
| Publisher: | Society of Nuclear Medicine |
| Date Published: | 2012-08-01 |
| Start Page: | 1171 |
| End Page: | 1174 |
| Language: | English |
| DOI: | 10.2967/jnumed.111.099770 |
| PROVIDER: | scopus |
| PUBMED: | 22789676 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 September 2012" - "CODEN: JNMEA" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work