Hypoxia imaging for image-guided radiotherapy Book Section
| Authors: | Le, Q. T.; Loo, B. W.; Lee, N. |
| Editors: | Tamaki, N.; Kuge, Y. |
| Article/Chapter Title: | Hypoxia imaging for image-guided radiotherapy |
| Abstract: | Tumor hypoxia, or the condition of low oxygen, is a key factor for tumor progression and treatment resistance. Because hypoxic tumor cells are more resistant to ionizing radiation, hypoxia has been a focus of clinical research in radiation therapy for half a century. During this period, interest in targeting tumor hypoxia has waxed and waned as promising treatments emerged from the laboratory, only to fail in the clinics. With the development of new radiation targeting strategies, specifically intensity-modulated radiotherapy (IMRT) and image guidance technologies (image-guided RT; IGRT), there is a strong interest in imaging hypoxia for radiation targeting and dose escalation. In this review, we will discuss the role of hypoxia imaging, specifically positron emission tomography (PET)-based imaging with hypoxia-specific tracers, for directing radiation treatment in solid tumors. |
| Keywords: | radiation; radiotherapy; hypoxia; imaging; pet; tumor hypoxia; advanced; positron-emission-tomography; gene-expression; prognostic-significance; neck-cancer; cell lung-cancer; head; fluoromisonidazole; f-18; dose painting; stereotactic body; glucose metabolic-rate |
| Book Title: | Molecular Imaging for Integrated Medical Therapy and Drug Development |
| ISBN: | 978-4-43198-073-5 |
| Publisher: | Springer |
| Publication Place: | Tokyo, Japan |
| Date Published: | 2010-01-01 |
| Start Page: | 7 |
| End Page: | 18 |
| Language: | English |
| ACCESSION: | WOS:000271884900002 |
| PROVIDER: | wos |
| DOI: | 10.1007/978-4-431-98074-2_2 |
| Notes: | Book Chapter: Section of Part I, "New Molecular Imaging and Image-Guided Radiotherapy" -- 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES -- Source: Wos |
