pH-responsive polymers for improving the signal-to-noise ratio of hypoxia PET imaging with [(18)F]fluoromisonidazole Research Letter
| Authors: | Goos, J. A. C. M.; Davydova, M.; Lengkeek, N.; Greguric, I.; Whittaker, M. R.; Quinn, J. F.; Baell, J. B.; Lewis, J. S.; Davis, T. P. |
| Title: | pH-responsive polymers for improving the signal-to-noise ratio of hypoxia PET imaging with [(18)F]fluoromisonidazole |
| Abstract: | To improve the signal-to-noise ratio of hypoxia positron emission tomography (PET) imaging, stimuli-responsive polymers are designed for the delivery of the hypoxia PET tracer fluorine-18 labeled fluoromisonidazole ([18F]FMISO). Linear poly(N-(2-(hydroxypropyl)methacrylamide)) polymers are functionalized with hydrazide linkers that form pH-sensitive acyl hydrazone bonds after their conjugation to an [18F]FMISO ketone analogue. The release of the [18F]FMISO ketone analogue from the polymers is considerably faster at a lower pH and its uptake is significantly higher in cancer cells growing under acidic conditions. Additionally, the retention of the PET tracer is significantly higher in hypoxic cells compared to normoxic cells. The delivery of a PET tracer using stimuli-responsive polymers may be an attractive strategy to improve signal-to-noise ratios in PET imaging. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
| Keywords: | positron emission tomography; hypoxia; positron emission tomography (pet); ketones; fluoromisonidazole; polymers; acidic conditions; functional polymers; signal to noise ratio; polyethylene terephthalates; stimuli-responsive materials; attractive strategies; ph-responsive polymer; stimuli-responsive polymer |
| Journal Title: | Macromolecular Rapid Communications |
| Volume: | 41 |
| Issue: | 11 |
| ISSN: | 1022-1336 |
| Publisher: | Wiley-VCH Verlag GmbH |
| Date Published: | 2020-06-01 |
| Start Page: | e2000061 |
| Language: | English |
| DOI: | 10.1002/marc.202000061 |
| PUBMED: | 32250004 |
| PROVIDER: | scopus |
| PMCID: | PMC8339940 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 July 2020 -- Source: Scopus |
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