Autophagy proteins in macroendocytic engulfment Journal Article
| Authors: | Florey, O.; Overholtzer, M. |
| Article Title: | Autophagy proteins in macroendocytic engulfment |
| Abstract: | Eukaryotic cells must constantly degrade both intracellular and extracellular material to maintain cellular and organismal homeostasis. Two engulfment pathways, autophagy and phagocytosis, contribute to the turnover of intracellular and extracellular substrates by delivering material to the lysosome. Historically these are thought to be separate pathways, but recent studies have revealed the direct participation of autophagy proteins in phagocytosis. Autophagy proteins lipidate LC3 onto phagosomes and other macroendocytic vacuole membranes, and are required for lysosomal degradation of engulfed cargo, demonstrating an autophagosome-independent role for autophagy proteins in mediating the turnover of extracellular substrates. This review discusses the biological systems in which autophagy proteins have been found to regulate lysosome fusion to non-autophagic membranes. © 2012 Elsevier Ltd. |
| Keywords: | signal transduction; unclassified drug; review; nonhuman; protein function; proteins; protein analysis; animals; protein; eukaryota; autophagy; phagocytosis; homeostasis; cell communication; endocytosis; phagosome; lysosome; lysosomes; cell vacuole; membrane fusion; entosis; vacuoles; engulfment; autophagy protein |
| Journal Title: | Trends in Cell Biology |
| Volume: | 22 |
| Issue: | 7 |
| ISSN: | 0962-8924 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2012-07-01 |
| Start Page: | 374 |
| End Page: | 380 |
| Language: | English |
| DOI: | 10.1016/j.tcb.2012.04.005 |
| PROVIDER: | scopus |
| PMCID: | PMC3383932 |
| PUBMED: | 22608991 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 August 2012" - "CODEN: TCBIE" - "Source: Scopus" |
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