Autophagy proteins regulate cell engulfment mechanisms that participate in cancer Journal Article
| Authors: | Kim, S. E.; Overholtzer, M. |
| Article Title: | Autophagy proteins regulate cell engulfment mechanisms that participate in cancer |
| Abstract: | Recent evidence has uncovered cross-regulation of mechanisms of cell engulfment by proteins of the autophagy pathway, in what is called LC3-Associated Phagocytosis, or LAP. By LAP, lysosome fusion to phagosomes and the degradation of engulfed extracellular cargo are facilitated by autophagy proteins that lipidate LC3 onto phagosome membranes. Here we discuss the contexts where LAP is known to occur by focusing on potential roles in tumorigenesis, including predicted consequences of LAP inhibition. © 2013 Elsevier Ltd. |
| Keywords: | cell death; tumor; autophagy; macrophage; phagocytosis; immune; entosis |
| Journal Title: | Seminars in Cancer Biology |
| Volume: | 23 |
| Issue: | 5 |
| ISSN: | 1044-579X |
| Publisher: | Academic Press Inc., Elsevier Science |
| Date Published: | 2013-10-01 |
| Start Page: | 329 |
| End Page: | 336 |
| Language: | English |
| DOI: | 10.1016/j.semcancer.2013.05.004 |
| PROVIDER: | scopus |
| PMCID: | PMC3791149 |
| PUBMED: | 23726896 |
| DOI/URL: | |
| Notes: | --- - Cited By (since 1996):1 - "Export Date: 1 November 2013" - "CODEN: SECBE" - "Source: Scopus" |
