Therapeutic targets in cancer cell metabolism and autophagy Journal Article
| Authors: | Cheong, H.; Lu, C.; Lindsten, T.; Thompson, C. B. |
| Article Title: | Therapeutic targets in cancer cell metabolism and autophagy |
| Abstract: | The metabolism of cancer cells is reprogrammed both by oncogene signaling and by dysregulation of metabolic enzymes. The resulting altered metabolism supports cellular proliferation and survival but leaves cancer cells dependent on a continuous supply of nutrients. Thus, many metabolic enzymes have become targets for new cancer therapies. Recently, two processes-expression of specific isoforms of metabolic enzymes and autophagy-have been shown to be crucial for the adaptation of tumor cells to changes in nutrient availability. An increasing number of approved and experimental therapeutics target these two processes. A better understanding of the molecular basis of cancer-associated metabolic changes may lead to improved cancer therapies. © 2012 Nature America, Inc. All rights reserved. |
| Keywords: | signal transduction; leukemia; unclassified drug; fludarabine; hydroxyurea; review; erlotinib; fluorouracil; advanced cancer; solid tumor; drug targeting; gemcitabine; methotrexate; temozolomide; glioma; antineoplastic agent; neoplasm; neoplasms; cell proliferation; metabolism; cell survival; gastrointestinal stromal tumor; imatinib; unindexed drug; melanoma; metastasis; bortezomib; mantle cell lymphoma; multiple myeloma; serine; lung non small cell cancer; dasatinib; chronic myeloid leukemia; oncology; cancer therapy; kidney carcinoma; acute lymphoblastic leukemia; physiology; temsirolimus; prostate cancer; oncogene; cutaneous t cell lymphoma; enzyme regulation; head and neck cancer; protein synthesis; cancer cell; nucleic acids; lymphoma; isoforms; vorinostat; asparaginase; brain cancer; glucose; amino acids; kidney cancer; autophagy; chronic lymphatic leukemia; therapeutic targets; pemetrexed; cell metabolism; multiple cancer; everolimus; obatoclax; panobinostat; salinosporamide a; rapamycin; enzymes; cancer cells; isosorbide; molecular basis; lonidamine; tumor cells; cells; glucose metabolism; metabolic networks and pathways; molecular targeted therapy; nutrient availability; fludarabine phosphate; nutrients; dacinostat; cellular proliferations; metabolic changes; metabolic enzymes; 2 dg; arginine deaminase; azd 3965; cap 23; daporinad; dichloroacetic acid; fk 8666; gmx 1777; n [6 (4 chlorophenoxy)hexyl] n' cyano n'' (4 pyridyl)guanidine; silibinin; tln 232 |
| Journal Title: | Nature Biotechnology |
| Volume: | 30 |
| Issue: | 7 |
| ISSN: | 1087-0156 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2012-07-10 |
| Start Page: | 671 |
| End Page: | 678 |
| Language: | English |
| DOI: | 10.1038/nbt.2285 |
| PROVIDER: | scopus |
| PUBMED: | 22781696 |
| PMCID: | PMC3876738 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 August 2012" - "CODEN: NABIF" - "Source: Scopus" |
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