Control of tumor-associated macrophage responses by nutrient acquisition and metabolism Review

   


Authors: Zhang, X.; Ji, L.; Li, M. O.
Review Title: Control of tumor-associated macrophage responses by nutrient acquisition and metabolism
Abstract: Metazoan tissue specification is associated with integration of macrophage lineage cells in sub-tissular niches to promote tissue development and homeostasis. Oncogenic transformation, most prevalently of epithelial cell lineages, results in maladaptation of resident tissue macrophage differentiation pathways to generate parenchymal and interstitial tumor-associated macrophages that largely foster cancer progression. In addition to growth factors, nutrients that can be consumed, stored, recycled, or converted to signaling molecules have emerged as crucial regulators of macrophage responses in tumor. Here, we review how nutrient acquisition through plasma membrane transporters and engulfment pathways control tumor-associated macrophage differentiation and function. We also discuss how nutrient metabolism regulates tumor-associated macrophages and how these processes may be targeted for cancer therapy. © 2022 Elsevier Inc.
Keywords: human cell; review; neoplasm; neoplasms; animal; metabolism; animals; cell differentiation; cancer therapy; cell membrane; tumor; nutrient; macrophage; macrophages; tumor-associated macrophage; transporter; tumor-associated macrophages; nutrients; engulfment; humans; human
Journal Title: Immunity
Volume: 56
Issue: 1
ISSN: 1074-7613
Publisher: Cell Press  
Date Published: 2023-01-10
Start Page: 14
End Page: 31
Language: English
DOI: 10.1016/j.immuni.2022.12.003
PUBMED: 36630912
PROVIDER: scopus
PMCID: PMC9839308
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85145772474&doi=10.1016%2fj.immuni.2022.12.003&partnerID=40&md5=a181ea40587e934e6d3046ca3614ed21
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF and PubMed. Corresponding author is MSK author Ming O. Li -- Export Date: 1 February 2023 -- Source: Scopus
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MSK Authors
  1. Ming Li
    110 Li
  2. Xian Zhang
    11 Zhang
  3. Liangliang Ji
    6 Ji
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