The utility of F-18 fluorodeoxyglucose whole body PET imaging for determining malignancy in cystic lesions of the pancreas Journal Article

  


Authors: Mansour, J. C.; Schwartz, L.; Pandit-Taskar, N.; D'Angelica, M.; Fong, Y.; Larson, S. M.; Brennan, M. F.; Allen, P. J.
Article Title: The utility of F-18 fluorodeoxyglucose whole body PET imaging for determining malignancy in cystic lesions of the pancreas
Abstract: Previous studies have suggested that whole body positron-emission tomography (PET) can distinguish between benign and malignant cysts of the pancreas. Patients were identified (n=68) who had undergone whole body PET imaging for a cystic lesion of the pancreas between Jan. 1997 and May 2005. Crosssectional imaging studies were reviewed by a single blinded radiologist, and positive PET studies were reviewed by a blinded nuclear medicine physician. Operative resection was performed in 21 patients (31%), and 47 patients were managed with radiographic follow-up. F-18 Fluorodeoxyglucose (FDG)avid lesions were identified In eight of the 68 patients (12%). Within the resected group of patients (n=21), four of the seven patients (57%) with either in situ or invasive malignancy (adenocarcinoma: 3 of 5, papillary mucinous carcinoma: 1 of 2) had positive PET imaging (mean SUV, 5.9; range 2.5-8.0), and 2 of the 14 patients (14%) with benign lesions had positive PET imaging (serous cystadenoma, n= 1, SUV=3.3; pseudocyst n=1, SUV=2.7). All lesions proven to be malignant with increased FDG uptake had highly suspicious findings on cross-sectional imaging. Within the group of resected patients, the sensitivity of PET for identifying malignant pathology was 57%, and the specificity was 85%. The sensitivity. 9 and specificity of PET for malignancy in this study was lower than previously reported, and PET findings did not identify other-wise occult malignant cysts. We do not believe whole body FDG-PET to be essential in the evaluation of cystic lesions of the pancreas.
Keywords: neoplasms; pancreas; tumors; management; ct; pet scan; cyst; positron-emission-tomography
Journal Title: Journal of Gastrointestinal Surgery
Volume: 10
Issue: 10
ISSN: 1091-255X
Publisher: Springer  
Date Published: 2006-12-01
Start Page: 1354
End Page: 1360
Language: English
ACCESSION: WOS:000243324900008
DOI: 10.1016/j.gassur.2006.08.002
PROVIDER: wos
PUBMED: 17175454
Notes: --- - Article - "Source: Wos"
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MSK Authors
  1. Murray F Brennan
    1053 Brennan
  2. John C Mansour
    6 Mansour
  3. Lawrence H Schwartz
    292 Schwartz
  4. Peter Allen
    500 Allen
  5. Yuman Fong
    775 Fong
  6. Neeta Pandit-Taskar
    316 Pandit-Taskar
  7. Michael D'Angelica
    715 D'Angelica
  8. Steven M Larson
    943 Larson
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