Prognostic significance of regulators of cell cycle and apoptosis, p16(INK4a), p53, and bcl-2 in primary mucosal melanomas of the head and neck Journal Article

   

Authors:	Prasad, M. L.; Patel, S. G.; Shah, J. P.; Hoshaw-Woodard, S.; Busam, K. J.
Article Title:	Prognostic significance of regulators of cell cycle and apoptosis, p16(INK4a), p53, and bcl-2 in primary mucosal melanomas of the head and neck
Abstract:	Abnormalities in cell cycle regulation, tumor suppressor gene functions and apoptosis are frequent events in tumorigenesis. Their role in the pathogenesis and prognosis of primary mucosal melanomas (MM) of the upper aerodigestive tract remains unknown. Sixty-four patients (40 men, 24 women, median age 64 years) with MM were included in this study; 32 had tumors in the nasal/paranasal cavities, 28 in the oral cavity and 4 in the pharynx. Archival tissues from 47 initial mucosal tumors, 17 mucosal recurrences, and 13 nodal/distant metastases were subjected to immunohistochemistry using antibodies against p16, p53, and bcl-2. The results were correlated with histological features and survival data. Expressions of p16, p53, and bcl-2 proteins were seen in 25% (N = 19/76), 21% (N = 16/76), and 74% (N = 56/76) of all tumors, respectively. bcl-2 expression in the initial tumors was associated with significantly longer overall and disease specific survival (3. 3 vs. 1. 5 years, P ≤ 0.05). Expression of p16 was increasingly lost, from 32% in initial tumors to 12% in recurrent and 15% in metastatic tumors (P = 0.06). Tumors comprised of undifferentiated cells were significantly more p53 positive than epithelioid or spindle cells (80% vs.33%, P = 0.02). Expression of these markers did not correlate with necrosis, or vascular and/or deep tissue invasion. Expression of bcl-2 is associated with better survival in MM. Loss of p16 was seen with tumor progression whereas aberrant p53 expression was frequent in undifferentiated tumor cells. © 2011 Springer Science+Business Media, LLC.
Keywords:	adult; aged; aged, 80 and over; middle aged; young adult; mortality; cancer staging; neoplasm staging; metabolism; cell cycle; protein bcl 2; melanoma; apoptosis; tumor markers, biological; pathology; protein p53; tumor marker; physiology; biosynthesis; head and neck neoplasms; tumor suppressor protein p53; cyclin dependent kinase inhibitor 2a; kaplan meier method; cyclin-dependent kinase inhibitor p16; tp53 protein, human; proto-oncogene proteins c-bcl-2; head and neck; head and neck tumor; p53; p16; mucous membrane; bcl-2; kaplan-meier estimate; mucosa; mucosal melanoma
Journal Title:	Head and Neck Pathology
Volume:	6
Issue:	2
ISSN:	1936-055X
Publisher:	Humana Press Inc
Date Published:	2012-06-01
Start Page:	184
End Page:	190
Language:	English
DOI:	10.1007/s12105-011-0319-2
PROVIDER:	scopus
PMCID:	PMC3370030
PUBMED:	22160615
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84862222481&partnerID=40&md5=2e22a6270f0e8c608aad0539408cc695
Notes:	--- - "Export Date: 2 July 2012" - "Source: Scopus"

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