Primary mucosal desmoplastic melanoma of the head and neck Journal Article
| Authors: | Prasad, M. L.; Patel, S. G.; Busam, K. J. |
| Article Title: | Primary mucosal desmoplastic melanoma of the head and neck |
| Abstract: | Background. Desmoplastic variants of melanoma rarely affect the mucosa. Methods. The clinicopathologic features and p53 status of seven primary mucosal desmoplastic melanomas of the oral and nasal cavity were studied. Results. The patients included six men and one woman (median age, 61 years; range, 23-74 years). Desmoplastic melanoma involved the lip in two, alveolus in three, buccal mucosa in one, and nasal vestibule in one patient. Three tumors infiltrated up to lamina propria, and three infiltrated bone and/or cartilage. All were amelanotic spindle cell tumors, five were neurotropic, and two were vasoinvasive. Aberrant p53 expression was seen in six tumors. All tumors recurred locally, and distant metastasis developed in three. Six patients died with disease (survival, 1-41 years; median, 8 years), and one patient was free of disease (survival, 20 years). Conclusions. Primary mucosal desmoplastic melanomas are clinically characterized by local recurrence and may lead to distant metastasis and death even after several years. Alterations in p53 expression are frequently associated with desmoplastic melanoma. © 2004 Wiley Periodicals, Inc. |
| Keywords: | adult; cancer survival; clinical article; human tissue; protein expression; aged; middle aged; mutation; clinical feature; cancer patient; lymphatic metastasis; disease association; melanoma; neoplasm recurrence, local; protein p53; cancer mortality; cancer invasion; head and neck cancer; bone; blood vessel; desmoplastic melanoma; spindle cell carcinoma; head and neck; mouth neoplasms; cheek mucosa; nose neoplasms; genes, p53; mouth cavity; nose cavity; cartilage; alveolar bone; lamina propria; lip; mucosal; desmoplastic; humans; human; male; female; priority journal; article |
| Journal Title: | Head & Neck |
| Volume: | 26 |
| Issue: | 4 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2004-04-01 |
| Start Page: | 373 |
| End Page: | 377 |
| Language: | English |
| DOI: | 10.1002/hed.10384 |
| PROVIDER: | scopus |
| PUBMED: | 15054741 |
| DOI/URL: | |
| Notes: | Head Neck -- Cited By (since 1996):29 -- Export Date: 16 June 2014 -- CODEN: HEANE -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work