Interaction of Wnt3a, Msgn1 and Tbx6 in neural versus paraxial mesoderm lineage commitment and paraxial mesoderm differentiation in the mouse embryo Journal Article


Authors: Nowotschin, S.; Ferrer-Vaquer, A.; Concepcion, D.; Papaioannou, V. E.; Hadjantonakis, A. K.
Article Title: Interaction of Wnt3a, Msgn1 and Tbx6 in neural versus paraxial mesoderm lineage commitment and paraxial mesoderm differentiation in the mouse embryo
Abstract: Paraxial mesoderm is the tissue which gives rise to the skeletal muscles and vertebral column of the body. A gene regulatory network operating in the formation of paraxial mesoderm has been described. This network hinges on three key factors, Wnt3a, Msgn1 and Tbx6, each of which is critical for paraxial mesoderm formation, since absence of any one of these factors results in complete absence of posterior somites. In this study we determined and compared the spatial and temporal patterns of expression of Wnt3a, Msgn1 and Tbx6 at a time when paraxial mesoderm is being formed. Then, we performed a comparative characterization of mutants in Wnt3a, Msgn1 and Tbx6. To determine the epistatic relationship between these three genes, and begin to decipher the complex interplay between them, we analyzed double mutant embryos and compared their phenotypes to the single mutants. Through the analysis of molecular markers in mutants, our data support the bipotential nature of the progenitor cells for paraxial mesoderm and establish regulatory relationships between genes involved in the choice between neural and mesoderm fates. © 2012 Elsevier Inc.
Keywords: mouse embryo; emt; gastrulation; progenitor cells; primitive streak; paraxial mesoderm; msgn1; neural ectoderm; somite; tbx6; wnt3a
Journal Title: Developmental Biology
Volume: 367
Issue: 1
ISSN: 0012-1606
Publisher: Elsevier Inc.  
Date Published: 2012-01-01
Start Page: 1
End Page: 14
Language: English
DOI: 10.1016/j.ydbio.2012.04.012
PROVIDER: scopus
PUBMED: 22546692
PMCID: PMC3367124
DOI/URL:
Notes: --- - "Export Date: 2 July 2012" - "CODEN: DEBIA" - "Source: Scopus"
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