Treadmill exercise inducing mild to moderate ischemia has no significant effect on skeletal muscle or cardiac (18)F-FDG uptake and image quality on subsequent whole-body PET scan Journal Article

  

Authors:	Lyall, A.; Capobianco, J.; Strauss, H. W.; Gonen, M.; Schoder, H.
Article Title:	Treadmill exercise inducing mild to moderate ischemia has no significant effect on skeletal muscle or cardiac (18)F-FDG uptake and image quality on subsequent whole-body PET scan
Abstract:	We report the effects of treadmill exercise on 18F-FDG uptake in skeletal muscles and image quality of torso PET and compare stress myocardial perfusion imaging patterns with myocardial 18F-FDG uptake. There were 3 groups of patients: 48 patients underwent PET within 8 h after a treadmill test (Ex 8), 45 patients within 48 h after a treadmill test (Ex 48), and 34 patients without prior exercise. Mean workload (8.4 ± 2.3 [Ex 8] vs. 8.9 ± 2.6 metabolic equivalents [Ex 48]) was similar in both exercise groups. Muscle uptake was assessed by standardized uptake value. Myocardial uptake patterns were compared visually. Minor differences between patient groups were noted only for maximum standardized uptake value in quadriceps muscles. There was no correlation between perfusion defects and myocardial 18F-FDG uptake patterns. Thus, treadmill exercise does not affect muscle 18F-FDG uptake or image quality on subsequent PET. Cardiac 18F-FDG uptake on torso PET scans is unrelated to myocardial perfusion status. Copyright © 2012 by the Society of Nuclear Medicine, Inc.
Keywords:	adolescent; adult; controlled study; aged; aged, 80 and over; middle aged; retrospective studies; major clinical study; radiopharmaceuticals; retrospective study; drug uptake; whole body imaging; quantitative analysis; image quality; fluorodeoxyglucose f 18; computer assisted emission tomography; fluorodeoxyglucose f18; positron-emission tomography; exercise test; treadmill exercise; heart muscle; myocardium; heart muscle ischemia; skeletal muscle; whole body pet; muscle, skeletal; myocardial perfusion imaging; fdg pet; myocardial ischemia; quadriceps femoris muscle
Journal Title:	Journal of Nuclear Medicine
Volume:	53
Issue:	6
ISSN:	0161-5505
Publisher:	Society of Nuclear Medicine
Date Published:	2012-06-01
Start Page:	917
End Page:	921
Language:	English
DOI:	10.2967/jnumed.111.101394
PROVIDER:	scopus
PUBMED:	22586146
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84861860424&partnerID=40&md5=891a58f6b1739e9138236e94f36bca42
Notes:	--- - "Export Date: 2 July 2012" - "CODEN: JNMEA" - "Source: Scopus"

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