PET/CT quantitation of the effect of patient-related factors on cardiac 18F-FDG uptake Journal Article
| Authors: | Israel, O.; Weiler-Sagie, M.; Rispler, S.; Bar-Shalom, R.; Frenkel, A.; Keidar, Z.; Bar-Shalev, A.; Strauss, H. W. |
| Article Title: | PET/CT quantitation of the effect of patient-related factors on cardiac 18F-FDG uptake |
| Abstract: | The effect of multiple patient-related factors on the degree of cardiac 18F-FDG uptake was assessed. Methods: Five hundred four consecutive patients undergoing routine 18F-FDG PET/CT studies completed a clinical questionnaire. 18F-FDG uptake was measured as the mean standardized uptake value within the heart delineated on the CT component of the study. Univariate and multivariate analyses assessed the influence of 51 clinical factors on cardiac 18F-FDG uptake. Results: On both multivariate and univariate analyses, cardiac 18F-FDG uptake was significantly lower in diabetics and in patients receiving bezafibrate or levothyroxine. Cardiac 18F-FDG uptake was significantly higher in men, patients younger than 30 y old, fasting duration of <5 h, patients with heart failure, and those receiving benzodiazepines. Conclusion: Cardiac 18F-FDG uptake was lower in patients receiving bezafibrate and levothyroxine and higher in patients receiving benzodiazepines. If further confirmed by prospectively designed studies, manipulation of these drugs may represent tools for optimized PET/CT imaging. Copyright © 2007 by the Society of Nuclear Medicine, Inc. |
| Keywords: | adult; aged; aged, 80 and over; middle aged; antibiotic agent; major clinical study; doxorubicin; positron emission tomography; radiopharmaceuticals; metabolism; unindexed drug; computer assisted tomography; heart disease; tomography, x-ray computed; steroid; questionnaire; diagnostic agent; drug uptake; quantitative analysis; acetylsalicylic acid; heart failure; nonsteroid antiinflammatory agent; diabetes mellitus; fluorodeoxyglucose f 18; fluorodeoxyglucose f18; positron-emission tomography; warfarin; radiopharmaceutical agent; scintiscanning; antidepressant agent; benzodiazepine derivative; insulin; epirubicin; aging; antilipemic agent; oral antidiabetic agent; multivariate analysis; idarubicin; anthracycline derivative; levothyroxine; whole body counting; whole-body counting; univariate analysis; beta adrenergic receptor blocking agent; bezafibrate; calcium channel blocking agent; dipeptidyl carboxypeptidase inhibitor; heart; drug interactions; diuretic agent; heart muscle; myocardium; omeprazole; pet/ct; heart diseases; drug interaction; serotonin uptake inhibitor; 18f-fdg; quantitation; allopurinol; thyroxine; bronchodilating agent; opiate derivative; antacid agent; diabetic patient; benzodiazepines; nitric acid derivative; cardiac uptake; antipyretic agent; statine derivative; antilipemic agents |
| Journal Title: | Journal of Nuclear Medicine |
| Volume: | 48 |
| Issue: | 2 |
| ISSN: | 0161-5505 |
| Publisher: | Society of Nuclear Medicine |
| Date Published: | 2007-02-01 |
| Start Page: | 234 |
| End Page: | 239 |
| Language: | English |
| PUBMED: | 17268020 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 12" - "Export Date: 17 November 2011" - "CODEN: JNMEA" - "Source: Scopus" |
