Strip mosaicing confocal microscopy for rapid imaging over large areas of excised tissue Conference Paper

  


Authors: Abeytunge, S.; Li, Y.; Larson, B.; Peterson, G.; Toledo-Crow, R.; Rajadhyaksha, M.
Title: Strip mosaicing confocal microscopy for rapid imaging over large areas of excised tissue
Conference Title: Advanced Biomedical and Clinical Diagnostic Systems X
Abstract: Confocal mosaicing microscopy is a developing technology platform for imaging tumor margins directly in fresh tissue, without the processing that is required for conventional pathology. Previously, basal cell carcinoma margins were detected by mosaicing of confocal images of 12 × 12 mm 2 of excised tissue from Mohs surgery. This mosaicing took 9 minutes. Recently we reported the initial feasibility of a faster approach called "strip mosaicing" on 10 × 10 mm 2 of tissue that was demonstrated in 3 minutes. In this paper we report further advances in instrumentation and software. Rapid mosaicing of confocal images on large areas of fresh tissue potentially offers a means to perform pathology at the bedside. Thus, strip mosaicing confocal microscopy may serve as an adjunct to pathology for imaging tumor margins to guide surgery. © 2012 SPIE.
Keywords: basal cell carcinoma; confocal microscopy; pathology; tumors; surgery; mohs surgery; mosaicing; surgical pathology; diseases; fresh tissues; rapid imaging; strip mosaicing; confocal image; technology platforms
Journal Title Proceedings of SPIE
Volume: 8214
Conference Dates: 2010 Jan 21
Conference Location: San Francisco, CA
ISBN: 0277-786X
Publisher: SPIE  
Location: San Francisco, CA
Date Published: 2012-01-01
Start Page: 821412
Language: English
DOI: 10.1117/12.909416
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84861945668&partnerID=40&md5=29272b6060ca5b5410693bb856f5e6b8
Notes: --- - Progress in Biomedical Optics and Imaging - Proceedings of SPIE - Progr. Biomed. Opt. Imaging Proc. SPIE - "Conference code: 90017" - "Export Date: 2 July 2012" - "Sponsors: The Society of Photo-Optical Instrumentation Engineers (SPIE)" - 22 January 2012 through 24 January 2012 - "Source: Scopus"
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MSK Authors
  1. Milind Rajadhyaksha
    222 Rajadhyaksha
  2. Ricardo Toledo-Crow
    25 Toledo-Crow
  3. Bjorg Larson
    11 Larson
  4. Sanjeewa Abeytunge
    32 Abeytunge
  5. Gary Peterson
    29 Peterson
  6. Yongbiao Li
    20 Li
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