Applications of total synthesis to problems in neurodegeneration: Fascinating chemistry along the way Journal Article
| Authors: | Wilson, R. M.; Danishefsky, S. J. |
| Article Title: | Applications of total synthesis to problems in neurodegeneration: Fascinating chemistry along the way |
| Abstract: | The possibility for the application of organic synthesis to the discovery of new agents in combating neurodegenerative disorders is described. Our focus has been on agents derived from natural-product leads and natural products themselves prepared through total synthesis. Herein, we describe some of the chemistry as well as interesting observations made along the way. © 2006 American Chemical Society. |
| Keywords: | chemistry; chemical structure; molecular structure; degenerative disease; synthesis; biological product; biological products; sesquiterpenes; neurodegenerative diseases; diterpene; lactones; sesquiterpene; diterpenes; bridged compounds; dioxoles; lactone; garsubellin a; triterpenes; tricycloillicinone; 11 o debenzoyltashironin; terpene; terpenes; scabronine g; jiadifenin; 11-o-debenzoyltashironin; bridged compound; 1,3 dioxolane derivative; merrilactone a; nga 0187; triterpene |
| Journal Title: | Accounts of Chemical Research |
| Volume: | 39 |
| Issue: | 8 |
| ISSN: | 0001-4842 |
| Publisher: | American Chemical Society |
| Date Published: | 2006-08-01 |
| Start Page: | 539 |
| End Page: | 549 |
| Language: | English |
| DOI: | 10.1021/ar068018n |
| PUBMED: | 16906750 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 39" - "Export Date: 4 June 2012" - "CODEN: ACHRE" - "Source: Scopus" |
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