On the remarkable antitumor properties of fludelone: How we got there Journal Article

  


Authors: Rivkin, A.; Chou, T. C.; Danishefsky, S. J.
Article Title: On the remarkable antitumor properties of fludelone: How we got there
Abstract: (Chemical Equation Presented) Small-molecule natural products are presumably often biosynthesized with a view to optimizing their ability to bind to strategic proteins or other biomolecular targets. Although the ultimate setting in which a drug must function may be very different, the use of such natural products as lead compounds can serve as a significant head start in the hunt for new agents of clinical value. Herein we reveal the synergistic relationship between chemical synthesis and drug optimization in the context of our research program around the epothilones: how synthesis led to the discovery of more-potent epothilone derivatives, and discovery inspired the development of new synthetic routes, thus demonstrating the value of target-directed total synthesis in the quest for new substances of material clinical benefit. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
Keywords: antineoplastic agents; antineoplastic agent; proteins; mouse; animal; animals; mice; drug development; biosynthesis; chemistry; short survey; chemical structure; molecular structure; biomolecules; synthesis; total synthesis; epothilones; epothilone derivative; natural products; drug products; fludelone; clinical value; anticancer drugs
Journal Title: Angewandte Chemie - International Edition
Volume: 44
Issue: 19
ISSN: 1433-7851
Publisher: Wiley Blackwell  
Date Published: 2005-05-06
Start Page: 2838
End Page: 2850
Language: English
DOI: 10.1002/anie.200461751
PUBMED: 15880547
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-18844378165&partnerID=40&md5=bf2dc729215755c29bf473e7a1871e27
Notes: --- - "Cited By (since 1996): 59" - "Export Date: 24 October 2012" - "CODEN: ACIEA" - "Source: Scopus"
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MSK Authors
  1. Alexey Rivkin
    10 Rivkin
  2. Samuel J Danishefsky
    539 Danishefsky
  3. Ting-Chao Chou
    319 Chou
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