Longitudinal MR spectroscopic imaging of pediatric diffuse pontine tumors to assess tumor aggression and progression Journal Article
| Authors: | Thakur, S. B.; Karimi, S.; Dunkel, I. J.; Koutcher, J. A.; Huang, W. |
| Article Title: | Longitudinal MR spectroscopic imaging of pediatric diffuse pontine tumors to assess tumor aggression and progression |
| Abstract: | Two pediatric patients with diffuse pontine tumors underwent MR spectroscopic imaging pre- and postradiation. Choline/creatine (Cho/Cr) and Cho/N-acetylaspartate (NAA) ratios were elevated before treatment, with no MR imaging contrast enhancement. These ratios were further elevated at 2 posttreatment follow-up studies, despite signs of excellent clinical improvement at initial follow-up. This study suggests that MR spectroscopic imaging is more specific in assessing the aggressiveness of diffuse pontine tumors than conventional MR imaging and can serve as a valuable tool in early prognostication. |
| Keywords: | child; school child; clinical feature; disease course; case report; cancer radiotherapy; radiation dose; neuroimaging; nuclear magnetic resonance imaging; follow up; methodology; magnetic resonance imaging; cancer mortality; symptom; disease progression; magnetic resonance spectroscopy; choline; creatine; nuclear magnetic resonance spectroscopy; headache; general condition improvement; pons angle tumor; brain stem tumor; brain stem neoplasms; n acetylaspartic acid; proton nuclear magnetic resonance; apparatus |
| Journal Title: | American Journal of Neuroradiology |
| Volume: | 27 |
| Issue: | 4 |
| ISSN: | 0195-6108 |
| Publisher: | American Society of Neuroradiology |
| Date Published: | 2006-04-01 |
| Start Page: | 806 |
| End Page: | 809 |
| Language: | English |
| PUBMED: | 16611768 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 12" - "Export Date: 4 June 2012" - "CODEN: AAJND" - "Source: Scopus" |
