OY-TES-1 expression and serum immunoreactivity in epithelial ovarian cancer Journal Article
| Authors: | Tammela, J.; Uenaka, A.; Ono, T.; Noguchi, Y.; Jungbluth, A. A.; Mhawech-Fauceglia, P.; Qian, F.; Schneider, S.; Sharma, S.; Driscoll, D.; Lele, S.; Old, L. J.; Nakayama, E.; Odunsi, K. |
| Article Title: | OY-TES-1 expression and serum immunoreactivity in epithelial ovarian cancer |
| Abstract: | OY-TES-1 is a novel target that belongs to the family of 'cancer/testis' (CT) antigens. Our goal was to examine the expression and immunogenicity of OY-TES-1 in epithelial ovarian cancer (EOC) to determine its potential as a target for vaccine therapy. OY-TES-1 expression was determined by one-step reverse transcriptase PCR on 100 EOC samples, 5 EOC cell lines, and a panel of normal tissues. Immunohistochemistry (IHC) was performed on the same panel of EOC tissues. Sera from a sub-group of patients were tested for OY-TES-1 antibody by ELISA. Thymus and leukocytes were weakly positive for OY-TES-1 while the remaining 5 normal tissues were negative. Expression of OY-TES-1 by either RT-PCR and/or IHC was demonstrable in 69/100 (69%) tumors. Humoral immunity to OY-TES-1 was demonstrated in 1/10 (10%) serum samples from patients whose tumors expressed the antigen. The median follow-up of the patient population was 34 months. There was no correlation between antigen expression and stage, grade, histology and survival. OY-TES-1 is expressed in 69% of patients with EOC, is absent from normal ovarian tissue, and a proportion of patients show evidence of a specific humoral immune response. These findings make OY-TES-1 an attractive target for antigen-specific immunotherapy in EOC. |
| Keywords: | immunohistochemistry; immunogenicity; antibody; prognostic indicator; ovarian tumor antigen |
| Journal Title: | International Journal of Oncology |
| Volume: | 29 |
| Issue: | 4 |
| ISSN: | 1019-6439 |
| Publisher: | Spandidos Publications |
| Date Published: | 2006-10-01 |
| Start Page: | 903 |
| End Page: | 910 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 16964386 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 8" - "Export Date: 4 June 2012" - "CODEN: IJONE" - "Source: Scopus" |
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