DNA vaccines against cancer Journal Article
| Authors: | Stan, R.; Wolchok, J. D.; Cohen, A. D. |
| Article Title: | DNA vaccines against cancer |
| Abstract: | Significant progress made in the field of tumor immunology by the characterization of a large number of tumor antigens, and the better understanding of the mechanisms preventing immune responses to malignancies has led to the extensive study of cancer immunization approaches such as DNA vaccines encoding tumor antigens. This article reviews major aspects of DNA immunization in cancer. It gives a brief history and then discusses the proposed mechanism of action, preclinical and clinical studies, and methods of enhancing the immune responses induced by DNA vaccines. © 2006 Elsevier Inc. All rights reserved. |
| Keywords: | treatment outcome; clinical trial; drug tolerability; review; drug safety; nonhuman; rituximab; neoplasms; antigen expression; prostate specific antigen; interleukin 2; unindexed drug; cancer immunotherapy; melanoma; immune system; imiquimod; cd40 ligand; granulocyte macrophage colony stimulating factor; interleukin 4; kidney carcinoma; immunological tolerance; hematologic malignancy; immune response; immunotherapy; gamma interferon; cancer vaccine; cancer vaccines; immunogenicity; tumor immunity; autoimmunity; innate immunity; dna vaccine; immunological adjuvant; immunomodulation; heat shock protein 70; immunity; flt3 ligand; adjuvants, immunologic; humoral immunity; vaccines, dna; intercellular adhesion molecule 1; lymphocyte function associated antigen 3; interleukin 12; interleukin 15; monocyte chemotactic protein 1; b7 antigen; cd86 antigen; tetanus toxoid; outer membrane protein a; protein vp22; nonviral gene delivery system; nonviral gene therapy; pseudomonas exotoxin; immunization; interleukin 18; delayed hypersensitivity; flagellin; secondary lymphoid tissue chemokine; rantes; macrophage inflammatory protein 1alpha; dna vector |
| Journal Title: | Hematology/Oncology Clinics of North America |
| Volume: | 20 |
| Issue: | 3 |
| ISSN: | 0889-8588 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2006-06-01 |
| Start Page: | 613 |
| End Page: | 636 |
| Language: | English |
| DOI: | 10.1016/j.hoc.2006.02.004 |
| PUBMED: | 16762727 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 13" - "Export Date: 4 June 2012" - "CODEN: HCNAE" - "Source: Scopus" |
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