Tumor antigens for cancer immunotherapy: Therapeutic potential of xenogeneic DNA vaccines Journal Article
| Authors: | Srinivasan, R.; Wolchok, J. D. |
| Article Title: | Tumor antigens for cancer immunotherapy: Therapeutic potential of xenogeneic DNA vaccines |
| Abstract: | Preclinical animal studies have convincingly demonstrated that tumor immunity to self antigens can be actively induced and can translate into an effective anti-tumor response. Several of these observations are being tested in clinical trials. Immunization with xenogeneic DNA is an attractive approach to treat cancer since it generates T cell and antibody responses. When working in concert, these mechanisms may improve the efficacy of vaccines. The use of xenogeneic DNA in overcoming immune tolerance has been promising not only in inbred mice with transplanted tumors but also in outbred canines, which present with spontaneous tumors, as in the case of human. Use of this strategy also overcomes limitations seen in other types of cancer vaccines. Immunization against defined tumor antigens using a xenogeneic DNA vaccine is currently being tested in early phase clinical trials for the treatment of melanoma and prostate cancers, with proposed trials for breast cancer and Non-Hodgkin's Lymphoma. © 2004 Srinivasan and Wolchok; licensee BioMed Central Ltd. |
| Keywords: | clinical trial; review; drug efficacy; drug safety; nonhuman; drug targeting; cancer staging; cd8 antigen; prostate specific antigen; canvaxin; unindexed drug; cancer immunotherapy; melanoma; breast cancer; protein targeting; carcinoembryonic antigen; granulocyte macrophage colony stimulating factor; antineoplastic activity; tyrosine; survivin; telomerase; tumor antigen; colorectal carcinoma; prostate cancer; rna; immunological tolerance; nonhodgkin lymphoma; immune response; immunoglobulin g; cancer vaccine; drug mechanism; ganglioside gd2; dog; immunogenicity; antibody response; tumor immunity; perforin; autoimmunity; dna vaccine; ganglioside gm3; cd4 antigen; melacine; t lymphocyte activation; ganglioside gd3; ganglioside gm2; b7 antigen; cd86 antigen; complementary dna; virus protein; immunoglobulin m; nonviral gene delivery system; plasmid dna; cd137 antigen; heat shock protein; acid phosphatase prostate isoenzyme; human; methyl cpg binding protein |
| Journal Title: | Journal of Translational Medicine |
| Volume: | 2 |
| ISSN: | 1479-5876 |
| Publisher: | Biomed Central Ltd |
| Date Published: | 2004-04-16 |
| Start Page: | 12 |
| Language: | English |
| DOI: | 10.1186/1479-5876-2-12 |
| PROVIDER: | scopus |
| PMCID: | PMC419720 |
| PUBMED: | 15090064 |
| DOI/URL: | |
| Notes: | J. Transl. Med. -- Cited By (since 1996):21 -- Export Date: 16 June 2014 -- Source: Scopus |
